Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 3/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13967031 | 0.82 | HRH3 (0.43) | HRH3 | |
| SCHEMBL12448239 | 0.81 | SLC18A3 (0.40) | CARM1PRMT6KCNQ3KCNQ2CHRM2 | |
| SCHEMBL24633511 | 0.81 | CARM1 (0.35) | CARM1PRMT6CHRM2HTR1AADRA2A | |
| SCHEMBL16065870 | 0.78 | LMNA (0.35) | CARM1PRMT6HRH3 | |
| SCHEMBL12384241 | 0.78 | GNAI3 (0.33) | CARM1PRMT6CYP2D6HTR4 | |
| SCHEMBL739693 | 0.78 | HRH3 (0.41) | KCNQ3KCNQ2HRH3 | |
| SCHEMBL22049253 | 0.78 | CARM1 (0.33) | CARM1PRMT6KCNQ3KCNQ2BCHE | |
| SCHEMBL21919650 | 0.77 | HRH3 (0.35) | KCNQ3KCNQ2HRH3 | |
| SCHEMBL23588755 | 0.77 | CYP2D6 (0.40) | CYP2D6HRH3BCHE | |
| SCHEMBL14706853 | 0.76 | HRH3 (0.46) | CARM1PRMT6KCNQ3KCNQ2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9718825-B2 | N-(4-(azaindazol-6-yl)-phenyl)-sulfonamides and their use as pharmaceuticals | SANOFI (FR) | 2017-08-01 | — | — | US | disclosed |