GPR34 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1122978	0.71	9/20
SCHEMBL476018	0.62	9/20
SCHEMBL476020	0.62	9/20
SCHEMBL1123312	0.59	9/20
SCHEMBL1123396	0.58	9/20
SCHEMBL1123398	0.57	9/20
SCHEMBL162609	0.56	9/20
SCHEMBL1123308	0.56	9/20
SCHEMBL1123291	0.55	9/20
SCHEMBL1123346	0.54	9/20
SCHEMBL313024	0.52	9/20
SCHEMBL1123288	0.49	9/20
SCHEMBL313387	0.60	8/20
SCHEMBL476022	0.60	8/20
SCHEMBL314002	0.56	8/20
SCHEMBL1122829	0.54	8/20
SCHEMBL1122724	0.49	8/20
SCHEMBL23963	0.75	7/20
Phosphatidyl Serine (SCHEMBL24649)	0.75	7/20
SCHEMBL25552	0.75	7/20

Clinical trials — most relevant to GPR34 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
Medication, Weight Gain and GI Hormones	PHASE4	COMPLETED
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
Studying the Influence of LEAP2 on Integrated Endocrine Control of Eating During Semaglutide Treatment	PHASE1/PHASE2	RECRUITING
A Single Dose Study to Determine the Excretion, Balance and Metabolic Disposition of Radiolabelled GW642444.	PHASE1	COMPLETED
The Role of Endocannabinoids in Insulin Production and Action	PHASE1	COMPLETED
GSK618334 Repeat Dose Study	PHASE1	COMPLETED
Assessment of [11C]ER176 to Image Translocator Protein in Brain and Whole Body of Healthy People	EARLY_PHASE1	COMPLETED
Oat Bran and Plasma Lipid and Fecal Bacteria in Coronary Artery Disease Patients	nan	COMPLETED
Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis	nan	WITHDRAWN
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance	nan	UNKNOWN
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation	nan	COMPLETED
Selective Activation of the Adrenomedullin Receptors in Migraine	nan	NOT_YET_RECRUITING
Investigating Optimal Propionate Delivery to the Colon Using Stable Isotope Labeling	nan	COMPLETED
Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers	nan	COMPLETED
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.	nan	COMPLETED
RCT to Describe the Effects of Colon Delivered Acetate, Propionate and Butyrate on Satiety and Glucose Homeostasis	nan	COMPLETED
Longitudinal Analysis of Amylin Levels in Migraine Patients Undergoing an Anti- CGRP/CGRPr Treatment	nan	NOT_YET_RECRUITING
PGE2/IL-22 Pathway in Various Forms of Eczema	nan	COMPLETED
Using Fenfluramine to Test the Serotonin Deficiency Theory of Depression	nan	NOT_YET_RECRUITING
Inflammation Impact on Pain in Knee Osteoarthritis	nan	COMPLETED
The Natural History of TRPV4 Neuropathy	nan	RECRUITING
Genetic Influences of Albuterol Response In Children With Bronchiolitis	nan	COMPLETED
Forced Oscillometry in Infants With Bronchopulmonary Dysplasia	nan	RECRUITING
5-HT7 Receptor Implication in Inflammatory Mechanisms in Multiple Sclerosis	nan	COMPLETED
mGluR5 Imaging in ALS Using PET	nan	UNKNOWN
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia	nan	UNKNOWN
Purinergic Signaling and the Postmenopausal Heart	nan	RECRUITING
Assessment of CXCL5 Level in SLE Patients and Its Correlation with Disease Activity	nan	NOT_YET_RECRUITING
Aromatase Inhibitor Clinical Trial	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a GPR34 binder may also engage these)

Protein	Name	Similarity
P60019	—	1.000	P60019 →
Q3SAG9	—	1.000	Q3SAG9 →
Q6XCF2	—	1.000	Q6XCF2 →
Q9R1K6	—	1.000	Q9R1K6 →
Q9BY21	—	0.988	Q9BY21 →
Q99MT7	—	0.987	Q99MT7 →
CYSLTR2	Cysteinyl leukotriene receptor 2	0.984	landscape →
Q3U507	—	0.983	Q3U507 →
GPR183	G-protein coupled receptor 183	0.983	landscape →
Q95N02	—	0.982	Q95N02 →
D4A4Q2	—	0.982	D4A4Q2 →
Q1RMI1	—	0.981	Q1RMI1 →
Q924T8	—	0.980	Q924T8 →
Q99JA4	—	0.980	Q99JA4 →
D4A7K7	—	0.980	D4A7K7 →
Q95N03	—	0.980	Q95N03 →
A5PLE7	—	0.980	A5PLE7 →
GPR174	Probable G-protein coupled receptor 174	0.980	landscape →
P47749	—	0.979	P47749 →
Q3ZBK9	—	0.979	Q3ZBK9 →
Q3U6B2	—	0.978	Q3U6B2 →
Q80Z39	—	0.978	Q80Z39 →
Q920E1	—	0.978	Q920E1 →
Q9ESG6	—	0.978	Q9ESG6 →
Q9CPV9	—	0.977	Q9CPV9 →
Q2NNR5	—	0.977	Q2NNR5 →
Q9XSD4	—	0.977	Q9XSD4 →
B0UXR0	—	0.977	B0UXR0 →
B5X337	—	0.976	B5X337 →
O08675	—	0.976	O08675 →