SCHEMBL1919482

SCHEMBL1919482

Cc1nc(C(C)C)c(-c2csc(C3(c4ccc(C(=O)NO)cc4)CC3)n2)[nH]1

nearest known ligand 0.35

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 5/20 0.35
HDAC1 Q13547 14/20 0.35
HDAC7 Q8WUI4 3/20 0.35
HDAC8 Q9BY41 3/20 0.35
HDAC4 P56524 1/20 0.35
HDAC9 Q9UKV0 1/20 0.35
HDAC5 Q9UQL6 1/20 0.35
HDAC3 O15379 4/20 0.34
NCOR2 Q9Y618 1/20 0.34
BAZ2A Q9UIF9 2/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HDAC2 Q92769 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1918782 0.86 HDAC1 (0.40) HDAC6HDAC1HDAC7HDAC8HDAC4
SCHEMBL1920118 0.82 HDAC6 (0.39) HDAC6HDAC1HDAC8HDAC3NCOR2
SCHEMBL3354545 0.75 HDAC6 (0.36) HDAC6HDAC1HDAC7HDAC8HDAC4
SCHEMBL1919031 0.74 HDAC1 (0.51) HDAC6HDAC1HDAC7HDAC8HDAC4
SCHEMBL1920586 0.74 HDAC6 (0.42) HDAC6HDAC1HDAC7HDAC8HDAC3
SCHEMBL1919479 0.74 CDK2 (0.45) HDAC6HDAC1HDAC3HDAC2
SCHEMBL1920158 0.72 ADORA3 (0.52) HDAC6KDM4EALDH1A1
SCHEMBL13494265 0.71 HDAC1 (0.46) HDAC6HDAC1HDAC7HDAC8HDAC4
SCHEMBL1919049 0.71 HDAC1 (0.53) HDAC6HDAC1HDAC7HDAC8HDAC4
SCHEMBL197109 0.69 CDK2 (0.47) HDAC6HDAC1HDAC7HDAC8HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2011529504-A 2011-12-08 JP claimed
EP-2326622-A1 CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE HISTONE DEACETYLASE INHIBITOR COMPOUNDS GILEAD SCIENCES, INC. (US) 2011-06-01 EP claimed
WO-2010014611-A1 CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE HISTONE DEACETYLASE INHIBITOR COMPOUNDS GILEAD COLORADO, INC. (US) 2010-02-04 WO claimed