Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 4/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1919272 | 0.85 | HDAC1 (0.40) | HDAC6HDAC3NCOR2HDAC1HDAC2 | |
| SCHEMBL1919482 | 0.82 | HDAC6 (0.35) | HDAC6HDAC3NCOR2HDAC1HDAC2 | |
| SCHEMBL2639027 | 0.78 | CAMK2D (0.54) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL2638094 | 0.77 | HDAC6 (0.36) | HDAC6HDAC3NCOR2HDAC1HDAC2 | |
| SCHEMBL657839 | 0.76 | HDAC6 (0.39) | HDAC6HDAC3NCOR2HDAC1HDAC2 | |
| SCHEMBL2638203 | 0.75 | HDAC6 (0.36) | HDAC6HDAC3NCOR2HDAC1HDAC2 | |
| SCHEMBL659119 | 0.75 | CDK2 (0.54) | HDAC6 | |
| SCHEMBL658895 | 0.75 | HDAC1 (0.50) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL658238 | 0.74 | HDAC6 (0.47) | HDAC6HDAC3NCOR2HDAC1HDAC2 | |
| SCHEMBL2638118 | 0.73 | CAMK2D (0.33) | HDAC6HDAC3NCOR2HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011529504-A | — | — | 2011-12-08 | — | — | JP | claimed |
| EP-2326622-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE HISTONE DEACETYLASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2011-06-01 | — | — | EP | claimed |
| WO-2010014611-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE HISTONE DEACETYLASE INHIBITOR COMPOUNDS | GILEAD COLORADO, INC. (US) | 2010-02-04 | — | — | WO | claimed |