Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | FSHR | P23945 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | BLK | P51451 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18916809 | 0.85 | POLB (0.48) | MAP4K1POLBTSHRFSHRMGLL | |
| SCHEMBL18916793 | 0.80 | JMJD6 (0.47) | MAP4K1POLBTSHRFSHRNPC1 | |
| SCHEMBL19194842 | 0.78 | NPC1 (0.47) | MAP4K1POLBTSHRFSHRMGLL | |
| SCHEMBL8129165 | 0.78 | POLB (0.51) | MAP4K1POLBTSHRFSHRMGLL | |
| SCHEMBL13529198 | 0.78 | MGLL (0.59) | POLBTSHRMGLLTP53MAPT | |
| SCHEMBL18916813 | 0.78 | TSHR (0.44) | MAP4K1POLBTSHRFSHRMGLL | |
| SCHEMBL19200589 | 0.77 | AAK1 (0.43) | MAP4K1MAPK1 | |
| SCHEMBL24707414 | 0.76 | NPC1 (0.52) | POLBMGLLNPC1RAB9AROCK2 | |
| SCHEMBL30001291 | 0.76 | NPC1 (0.52) | POLBMGLLNPC1RAB9AROCK2 | |
| SCHEMBL5143604 | 0.76 | DEGS1 (0.65) | POLBTSHRFSHRMGLLTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190071441-A1 | PYRAZOLE DERIVATIVE MANUFACTURING METHOD | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2019-03-07 | — | — | US | disclosed |
| US-10174025-B2 | Pyrazole derivative manufacturing method | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2019-01-08 | — | — | US | disclosed |
| US-20180099964-A1 | PYRAZOLE DERIVATIVE MANUFACTURING METHOD | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2018-04-12 | — | — | US | disclosed |
| US-20180099964-A1 | PYRAZOLE DERIVATIVE MANUFACTURING METHOD | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2018-04-12 | — | — | US | disclosed |
| US-9879009-B2 | Pyrazole derivative manufacturing method | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2018-01-30 | — | — | US | disclosed |
| US-9879009-B2 | Pyrazole derivative manufacturing method | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2018-01-30 | — | — | US | disclosed |
| US-20170217958-A1 | PYRAZOLE DERIVATIVE MANUFACTURING METHOD | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2017-08-03 | — | — | US | disclosed |
| US-20170217958-A1 | PYRAZOLE DERIVATIVE MANUFACTURING METHOD | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2017-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217958-A1 | PYRAZOLE DERIVATIVE MANUFACTURING METHOD | CYP3A7, CYP2C19, CYP3A5 | MAP4K1 1366/4885POLB 2315/4885TSHR 1311/4885 |
| US-10174025-B2 | Pyrazole derivative manufacturing method | CYP3A5, CYP3A7, CYP3A4 | MAP4K1 971/4885POLB 2619/4885TSHR 1457/4885 |
| US-20180099964-A1 | PYRAZOLE DERIVATIVE MANUFACTURING METHOD | CYP3A5, CYP3A7, CYP3A4 | MAP4K1 971/4885POLB 2619/4885TSHR 1457/4885 |
| US-20190071441-A1 | PYRAZOLE DERIVATIVE MANUFACTURING METHOD | CYP3A5, CYP3A7, CYP3A4 | MAP4K1 971/4885POLB 2619/4885TSHR 1457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.