Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19195385 | 1.00 | NFE2L2 (0.33) | NFE2L2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL19196386 | 0.81 | NFE2L2 (0.39) | NFE2L2 | |
| SCHEMBL19196387 | 0.78 | NFE2L2 (0.37) | NFE2L2 | |
| SCHEMBL19195387 | 0.78 | NFE2L2 (0.37) | NFE2L2 | |
| SCHEMBL19195532 | 0.76 | NFE2L2 (0.35) | NFE2L2 | |
| SCHEMBL19195298 | 0.76 | NFE2L2 (0.35) | NFE2L2 | |
| SCHEMBL19195531 | 0.74 | NFE2L2 (0.34) | NFE2L2 | |
| SCHEMBL19196399 | 0.73 | NFE2L2 (0.33) | NFE2L2 | |
| SCHEMBL19196407 | 0.73 | NFE2L2 (0.33) | NFE2L2 | |
| SCHEMBL19195155 | 0.73 | NFE2L2 (0.36) | NFE2L2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9845307-B2 | Nrf2 activating compounds and uses thereof | MIDCAP FINANCIAL TRUST | 2017-12-19 | — | — | US | disclosed |
| US-20170217922-A1 | Nrf2 Activating Compounds and Uses Thereof | MIDCAP FINANCIAL TRUST | 2017-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217922-A1 | Nrf2 Activating Compounds and Uses Thereof | NFE2L2, KEAP1, NQO1 | NFE2L2 1/4885CYP1A2 3175/4885CYP3A4 3837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.