Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CASP3 | P42574 | 2/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | VCP | P55072 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29482430 | 1.00 | CYP19A1 (0.62) | CYP19A1NPC1RAB9AKDM4EMAPT | |
| Hydrochloric Acid SCHEMBL5534558 | 0.98 | CYP19A1 (0.60) | CYP19A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL25168239 | 0.89 | CYP19A1 (0.72) | CYP19A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL1606293 | 0.82 | NPC1 (0.65) | CYP19A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL1606452 | 0.81 | CYP19A1 (0.62) | CYP19A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL4247549 | 0.81 | CYP19A1 (0.62) | CYP19A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL1606850 | 0.81 | CYP19A1 (0.62) | CYP19A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL7948626 | 0.77 | RAB9A (0.66) | CYP19A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL1605308 | 0.77 | CYP19A1 (0.57) | CYP19A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL25455013 | 0.77 | CDK5 (0.76) | CYP19A1NPC1RAB9AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091959-B1 | NOVEL PYRROLO-(3,4-B)QUINOLINE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF AS A MEDICAMENT | MACEF (FR) | 2002-10-23 | — | — | EP | claimed |
| US-6335346-B1 | HYPNOTIC AGENTS, SEDATIVES | MACEF (FR) | 2002-01-01 | — | — | US | claimed |
| EP-0705262-A1 | PROCESS FOR ASYMMETRIC TOTAL SYNTHESIS OF CAMPTOTHECIN | SMITHKLINE BEECHAM CORPORATION (US) | 1996-04-10 | — | — | EP | claimed |
| EP-0705262-A4 | PROCESS FOR ASYMMETRIC TOTAL SYNTHESIS OF CAMPTOTHECIN | SMITHKLINE BEECHAM CORP (US) | 1996-02-13 | — | — | EP | claimed |
| EP-0660835-A4 | PROCESS FOR PREPARING CERTAIN PYRROLO 3,4- -I(B))QUINOLINES, CERTAIN 1H-PYRANO 3',4':6,7)INDOLIZINO 1,2--I(B))QUINOLIN-3,14(4H,12H)-DIONES, AND CERTAIN 8-METHYL-7-(OXOPROPYL)-INDOLIZINO 1,2--I(B))QUINOLIN-9(11H)-ONES. | — | 1995-08-16 | — | — | EP | claimed |
| EP-0660835-A1 | PROCESS FOR PREPARING CERTAIN PYRROLO 3,4- $i(b)]QUINOLINES, CERTAIN 1H-PYRANO 3',4':6,7]INDOLIZINO 1,2-$i(b)]QUINOLIN-3,14(4H,12H)-DIONES, AND CERTAIN 8-METHYL-7-(OXOPROPYL)-INDOLIZINO 1,2-$i(b)]QUINOLIN-9(11H)-ONES | SMITHKLINE BEECHAM CORPORATION (US) | 1995-07-05 | — | — | EP | claimed |
| US-5405963-A | Process for asymmetric total synthesis of camptothecin analogues | SMITHKLINE BEECHAM CORPORATION (US) | 1995-04-11 | — | — | US | claimed |
| WO-1994029310-A1 | PROCESS FOR ASYMMETRIC TOTAL SYNTHESIS OF CAMPTOTHECIN | SMITHKLINE BEECHAM CORPORATION (US) | 1994-12-22 | — | — | WO | claimed |
| CN-1096297-A | The method of synthetic camptothecine and Mai Pi star and their analogue and allied compound | SMITHKLINE BEECHAM CORP (US) | 1994-12-14 | — | — | CN | claimed |
| WO-1994005672-A1 | PROCESS FOR PREPARING CERTAIN PYRROLO[3,4- b]QUINOLINES, CERTAIN 1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-b]QUINOLIN-3,14(4H,12H)-DIONES, AND CERTAIN 8-METHYL-7-(OXOPROPYL)-INDOLIZINO[1,2-b]QUINOLIN-9(11H)-ONES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-03-17 | — | — | WO | claimed |
| US-11932640-B1 | Pyrrolo[3,4-b]quinoline compounds as antibacterial agents | King Faisal University (SA) | 2024-03-19 | — | — | US | disclosed |
| US-11932640-B1 | Pyrrolo[3,4-b]quinoline compounds as antibacterial agents | King Faisal University (SA) | 2024-03-19 | — | — | US | disclosed |
| US-11932640-B1 | Pyrrolo[3,4-b]quinoline compounds as antibacterial agents | King Faisal University (SA) | 2024-03-19 | — | — | US | disclosed |
| US-11807639-B1 | Pyrrolo[3,4-b]quinoline compounds as antibacterial agents | King Faisal University (SA) | 2023-11-07 | — | — | US | disclosed |
| US-11807639-B1 | Pyrrolo[3,4-b]quinoline compounds as antibacterial agents | King Faisal University (SA) | 2023-11-07 | — | — | US | disclosed |
| WO-1994029310-A1 | PROCESS FOR ASYMMETRIC TOTAL SYNTHESIS OF CAMPTOTHECIN | SMITHKLINE BEECHAM CORPORATION (US) | 1994-12-22 | — | — | WO | disclosed |
| CN-1096297-A | The method of synthetic camptothecine and Mai Pi star and their analogue and allied compound | SMITHKLINE BEECHAM CORP (US) | 1994-12-14 | — | — | CN | disclosed |
| CN-1096297-A | The method of synthetic camptothecine and Mai Pi star and their analogue and allied compound | SMITHKLINE BEECHAM CORP (US) | 1994-12-14 | — | — | CN | disclosed |
| WO-1994005672-A1 | PROCESS FOR PREPARING CERTAIN PYRROLO[3,4- b]QUINOLINES, CERTAIN 1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-b]QUINOLIN-3,14(4H,12H)-DIONES, AND CERTAIN 8-METHYL-7-(OXOPROPYL)-INDOLIZINO[1,2-b]QUINOLIN-9(11H)-ONES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-03-17 | — | — | WO | disclosed |
| WO-1994005672-A1 | PROCESS FOR PREPARING CERTAIN PYRROLO[3,4- b]QUINOLINES, CERTAIN 1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-b]QUINOLIN-3,14(4H,12H)-DIONES, AND CERTAIN 8-METHYL-7-(OXOPROPYL)-INDOLIZINO[1,2-b]QUINOLIN-9(11H)-ONES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11932640-B1 | Pyrrolo[3,4-b]quinoline compounds as antibacterial agents | POLB, POLA1, POLR2B | CYP19A1 3870/4885NPC1 4511/4885RAB9A 1218/4885 |
| US-11807639-B1 | Pyrrolo[3,4-b]quinoline compounds as antibacterial agents | POLB, TOP2A, POLI | CYP19A1 4321/4885NPC1 4579/4885RAB9A 1299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.