Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29688609 | 0.76 | AKR1B1 (0.44) | AKR1B1PTGER3LMNA | |
| SCHEMBL20135344 | 0.76 | AKR1B1 (0.44) | AKR1B1PTGER3LMNA | |
| SCHEMBL15974325 | 0.74 | LMNA (0.47) | AKR1B1PTGER3LMNA | |
| SCHEMBL15972677 | 0.71 | LMNA (0.47) | AKR1B1PTGER3LMNAKDM4EALDH1A1 | |
| SCHEMBL542561 | 0.68 | LMNA (0.53) | AKR1B1LMNAHSD17B10ALDH1A1MAPT | |
| SCHEMBL20134878 | 0.68 | LMNA (0.53) | AKR1B1LMNAHSD17B10ALDH1A1MAPT | |
| SCHEMBL10822849 | 0.66 | TAAR1 (0.43) | KDM4EHSD17B10APOBEC3ACTDSP1APOBEC3G | |
| SCHEMBL6099453 | 0.66 | LMNA (0.51) | LMNAALDH1A1MAPTADAMTS5MEN1 | |
| SCHEMBL9629541 | 0.65 | TAAR1 (0.42) | KDM4EHSD17B10APOBEC3ACTDSP1APOBEC3G | |
| SCHEMBL20135216 | 0.65 | PTGER3 (0.40) | AKR1B1PTGER3LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401261-A1 | N-PHENYLACETAMIDE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1 AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | Galderma Research & Development (FR) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097467-A1 | N-PHENYLACETAMIDE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1 AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-09-02 | — | — | WO | disclosed |