Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TDP2 | O95551 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 3/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1812108 | 0.82 | ALDH1A1 (0.45) | TDP1KDM4EBLMALDH1A1CYP3A4 | |
| SCHEMBL31278612 | 0.77 | ALDH1A1 (0.44) | TDP1KDM4ETDP2BLMNSD2 | |
| SCHEMBL17449213 | 0.77 | ALDH1A1 (0.44) | TDP1KDM4ETDP2BLMNSD2 | |
| SCHEMBL29601706 | 0.74 | KDM4E (0.46) | TDP1KDM4EBLMMEN1KMT2A | |
| SCHEMBL6902624 | 0.74 | KDM4E (0.46) | TDP1KDM4EBLMMEN1KMT2A | |
| SCHEMBL30578386 | 0.72 | KDM4E (0.45) | TDP1KDM4EBLMHCRTR1HCRTR2 | |
| SCHEMBL6174571 | 0.72 | MAPT (0.55) | TDP1KDM4EALDH1A1MAPT | |
| SCHEMBL21374133 | 0.72 | PRKCA (0.54) | CYP3A4 | |
| SCHEMBL28480001 | 0.72 | KDM4E (0.50) | TDP1KDM4ETDP2BLMNSD2 | |
| SCHEMBL17506235 | 0.71 | MAPT (0.43) | TDP1KDM4EBLMTRPV1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10183953-B2 | Substituted 2-azabicycles and their use as orexin receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-22 | — | — | US | disclosed |
| US-20170204096-A1 | Substituted 2-Azabicycles And Their Use As Orexin Receptor Modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10183953-B2 | Substituted 2-azabicycles and their use as orexin receptor modulators | HCRTR2, HCRTR1, NPY2R | TDP1 4658/4885KDM4E 1236/4885TDP2 4520/4885 |
| US-20170204096-A1 | Substituted 2-Azabicycles And Their Use As Orexin Receptor Modulators | HCRTR2, HCRTR1, NPY2R | TDP1 4658/4885KDM4E 1236/4885TDP2 4520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.