Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 6/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.43 |
| ▸ | CA1 | P00915 | 6/20 | 0.41 |
| ▸ | CA2 | P00918 | 6/20 | 0.41 |
| ▸ | CA12 | O43570 | 5/20 | 0.41 |
| ▸ | CA9 | Q16790 | 5/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19201250 | 0.84 | PPARA (0.47) | PPARAPPARGPPARDMTNR1AMTNR1B | |
| SCHEMBL3805722 | 0.81 | MTNR1A (0.51) | PPARAPPARGPPARDMTNR1AMTNR1B | |
| SCHEMBL13191484 | 0.76 | CNR1 (0.49) | CA1CA2CA12CA9MTNR1A | |
| SCHEMBL19360364 | 0.75 | EPHX2 (0.49) | CA1CA2CA12CA9 | |
| SCHEMBL13191491 | 0.75 | PPARA (0.48) | PPARAPPARGPPARDHDAC1 | |
| SCHEMBL192397 | 0.75 | APLNR (0.56) | POLB | |
| SCHEMBL7652554 | 0.73 | NPC1 (0.58) | HDAC1 | |
| SCHEMBL25594014 | 0.72 | GFER (0.47) | — | |
| SCHEMBL1654408 | 0.72 | PLA2G1B (0.48) | PPARAHDAC1TRPV1 | |
| SCHEMBL12231290 | 0.70 | POLB (0.44) | MTNR1AMTNR1BTRPV1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017132432-A1 | BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF ROR-GAMMA | VITAE PHARMACEUTICALS, INC. (US) | 2017-08-03 | — | — | WO | disclosed |