Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 19/20 | 0.58 |
| ▸ | MC5R | P33032 | 5/20 | 0.57 |
| ▸ | MC1R | Q01726 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MC3R | P41968 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18914400 | 0.86 | MC4R (0.52) | MC4RMC5RMC1R | |
| SCHEMBL18914407 | 0.86 | MC4R (0.52) | MC4RMC5RMC1R | |
| SCHEMBL3170726 | 0.86 | MC4R (0.61) | MC4RMC5RMC1RMC3RKCNH2 | |
| SCHEMBL3170723 | 0.86 | MC4R (0.61) | MC4RMC5RMC1RMC3RKCNH2 | |
| SCHEMBL29327391 | 0.85 | MC1R (0.51) | MC4RMC5RMC1R | |
| SCHEMBL1920165 | 0.85 | MC1R (0.51) | MC4RMC5RMC1R | |
| Hydrochloric Acid SCHEMBL1920194 | 0.85 | MC4R (0.63) | MC4RMC5RMC1RMC3RKCNH2 | |
| Hydrochloric Acid SCHEMBL3170453 | 0.85 | MC4R (0.63) | MC4RMC5RMC1RMC3RKCNH2 | |
| SCHEMBL1920357 | 0.84 | MC4R (0.56) | MC4RMC5R | |
| SCHEMBL18914401 | 0.83 | MC4R (0.47) | MC4RMC5RMC1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716135-B1 | PIPERIDINYLCARBONYL-PYRROLIDINES AND THEIR USE AS MELANOCORTIN AGONISTS | PFIZER LTD (GB) | 2011-06-01 | — | — | EP | disclosed |
| US-7649002-B2 | (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists | PFIZER INC (US) | 2010-01-19 | — | — | US | disclosed |