Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 3/20 | 0.56 |
| ▸ | MC5R | P33032 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1920280 | 0.85 | MC4R (0.60) | MC4RMC5RMEN1KMT2A | |
| SCHEMBL1920425 | 0.85 | MC4R (0.60) | MC4RMC5RMEN1KMT2A | |
| SCHEMBL1920168 | 0.84 | MC4R (0.58) | MC4RMC5R | |
| SCHEMBL1920864 | 0.84 | MC4R (0.59) | MC4RMC5R | |
| SCHEMBL18914642 | 0.84 | MC4R (0.59) | MC4RMC5R | |
| SCHEMBL1920254 | 0.84 | MC4R (0.59) | MC4RMC5R | |
| SCHEMBL18914407 | 0.82 | MC4R (0.52) | MC4RMC5R | |
| SCHEMBL18914400 | 0.82 | MC4R (0.52) | MC4RMC5R | |
| SCHEMBL18914417 | 0.80 | PDE4B (0.59) | MC4RMC5R | |
| SCHEMBL18914504 | 0.80 | MC4R (0.48) | MC4RMC5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716135-B1 | PIPERIDINYLCARBONYL-PYRROLIDINES AND THEIR USE AS MELANOCORTIN AGONISTS | PFIZER LTD (GB) | 2011-06-01 | — | — | EP | disclosed |
| EP-1716135-B1 | PIPERIDINYLCARBONYL-PYRROLIDINES AND THEIR USE AS MELANOCORTIN AGONISTS | PFIZER LTD (GB) | 2011-06-01 | — | — | EP | disclosed |
| US-7649002-B2 | (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists | PFIZER INC (US) | 2010-01-19 | — | — | US | disclosed |
| US-7649002-B2 | (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists | PFIZER INC (US) | 2010-01-19 | — | — | US | disclosed |