Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | FURIN | P09958 | 5/20 | 0.31 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.31 |
| ▸ | GLP1R | P43220 | 3/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19171240 | 0.92 | SIRT5 (0.37) | SIRT5SIRT2MEN1KMT2AFURIN | |
| SCHEMBL18122900 | 0.85 | SIRT5 (0.36) | SIRT5SIRT2FURIN | |
| SCHEMBL17381414 | 0.84 | SIRT5 (0.39) | SIRT5MEN1KMT2AFURINC3AR1 | |
| SCHEMBL19170447 | 0.83 | SIRT5 (0.34) | SIRT5SIRT2MEN1KMT2AMAPT | |
| SCHEMBL24722146 | 0.81 | SIRT5 (0.34) | SIRT5SIRT2 | |
| SCHEMBL19170726 | 0.81 | SIRT5 (0.42) | SIRT5SIRT2KMT2AFURINC3AR1 | |
| SCHEMBL19171339 | 0.81 | SIRT5 (0.42) | SIRT5SIRT2KMT2AFURINC3AR1 | |
| SCHEMBL23586838 | 0.79 | FURIN (0.39) | SIRT5FURINC3AR1 | |
| SCHEMBL19170685 | 0.78 | NMT2 (0.40) | SIRT5FURIN | |
| SCHEMBL21534501 | 0.78 | SIRT5 (0.33) | SIRT5FURIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3273998-B1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | REGENERON PHARMA (US) | 2019-09-04 | — | — | EP | disclosed |
| WO-2017132173-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | REGENERON PHARMACEUTICALS, INC. (US) | 2017-08-03 | — | — | WO | disclosed |