Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29828077 | 0.84 | RAB9A (0.57) | RAB9ASMN1; SMN2NPC1HSD17B10ALDH1A1 | |
| SCHEMBL12147147 | 0.84 | RAB9A (0.57) | RAB9ASMN1; SMN2NPC1HSD17B10ALDH1A1 | |
| SCHEMBL12145802 | 0.82 | RAB9A (0.53) | RAB9ASMN1; SMN2NPC1HSD17B10ALDH1A1 | |
| SCHEMBL11915950 | 0.81 | RAB9A (0.51) | RAB9ASMN1; SMN2NPC1HSD17B10ALDH1A1 | |
| SCHEMBL11919082 | 0.81 | RAB9A (0.62) | RAB9ASMN1; SMN2NPC1HSD17B10ALDH1A1 | |
| SCHEMBL17712744 | 0.72 | RAB9A (0.60) | RAB9ASMN1; SMN2NPC1HSD17B10ALDH1A1 | |
| Nicotinyl Methylamide SCHEMBL129458 | 0.71 | HDAC1 (0.69) | ALDH1A1KDM4ELMNAHIF1AROCK2 | |
| Nicotinyl Methylamide SCHEMBL30664356 | 0.71 | HDAC1 (0.69) | ALDH1A1KDM4ELMNAHIF1AROCK2 | |
| Nicotinyl Methylamide SCHEMBL28560459 | 0.71 | HDAC1 (0.69) | ALDH1A1KDM4ELMNAHIF1AROCK2 | |
| Nicotinyl Methylamide SCHEMBL22190418 | 0.70 | HDAC1 (0.67) | ALDH1A1KDM4ELMNAHIF1AROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170218000-A1 | PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. | 2017-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170218000-A1 | PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS | MAP3K6, PIK3CA, MAP3K20 | RAB9A 1513/4885SMN1; SMN2 4512/4885NPC1 3672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.