Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 19/20 | 0.45 |
| ▸ | MC5R | P33032 | 6/20 | 0.44 |
| ▸ | MC1R | Q01726 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | MC3R | P41968 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1920169 | 0.85 | MC1R (0.47) | MC4RMC5RMC1RKCNH2MC3R | |
| SCHEMBL1920759 | 0.83 | MC4R (0.45) | MC4RMC5RMC1RKCNH2MC3R | |
| SCHEMBL1920256 | 0.80 | MC4R (0.48) | MC4RMC5RMC1RKCNH2MC3R | |
| SCHEMBL1920885 | 0.80 | MC4R (0.48) | MC4RMC5RMC1RKCNH2MC3R | |
| SCHEMBL3170726 | 0.75 | MC4R (0.61) | MC4RMC5RMC1RKCNH2MC3R | |
| SCHEMBL3170723 | 0.75 | MC4R (0.61) | MC4RMC5RMC1RKCNH2MC3R | |
| Hydrochloric Acid SCHEMBL3170453 | 0.74 | MC4R (0.63) | MC4RMC5RMC1RKCNH2MC3R | |
| Hydrochloric Acid SCHEMBL1920194 | 0.74 | MC4R (0.63) | MC4RMC5RMC1RKCNH2MC3R | |
| SCHEMBL2307986 | 0.72 | PANK3 (0.42) | MC4RMC5RKCNH2MC3R | |
| SCHEMBL1919958 | 0.72 | MC4R (0.40) | MC4RMC5RMC1RKCNH2MC3R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716135-B1 | PIPERIDINYLCARBONYL-PYRROLIDINES AND THEIR USE AS MELANOCORTIN AGONISTS | PFIZER LTD (GB) | 2011-06-01 | — | — | EP | disclosed |