Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.30 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.30 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.30 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29688902 | 0.82 | MAPT (0.41) | ADORA2AADORA2B | |
| SCHEMBL5769361 | 0.82 | MAPT (0.41) | ADORA2AADORA2B | |
| SCHEMBL13122336 | 0.81 | ADORA2A (0.49) | ADORA2AADORA2BCFTRMAPK1MAP2K4 | |
| SCHEMBL19249596 | 0.81 | GPR84 (0.39) | — | |
| SCHEMBL22890172 | 0.78 | CHEK1 (0.34) | — | |
| SCHEMBL19204854 | 0.78 | AR (0.35) | — | |
| SCHEMBL38661124 | 0.78 | PDPK1 (0.31) | — | |
| SCHEMBL31411446 | 0.77 | TAAR1 (0.36) | CFTRMAP2K4 | |
| SCHEMBL27221751 | 0.76 | AR (0.35) | ADORA2AADORA2B | |
| SCHEMBL13122067 | 0.75 | MAPK1 (0.34) | ADORA2AADORA2BCFTRMAPK1MAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017133667-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA THEREOF | SAVIRA PHARMACEUTICALS GMBH (AT) | 2017-08-10 | — | — | WO | disclosed |
| WO-2017133670-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA | SAVIRA PHARMACEUTICALS GMBH (AT) | 2017-08-10 | — | — | WO | disclosed |