Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | TOP2A | P11388 | 2/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29779877 | 1.00 | GPR3 (0.61) | GPR3KDM4ETOP2AADORA3PDPK1 | |
| SCHEMBL27816324 | 0.98 | GPR3 (0.59) | GPR3KDM4ETOP2AADORA3PDPK1 | |
| Phenanthridine SCHEMBL30823553 | 0.76 | GPR3 (1.00) | GPR3KDM4ETOP2AADORA3PDPK1 | |
| Phenanthridine SCHEMBL8666 | 0.76 | GPR3 (1.00) | GPR3KDM4ETOP2AADORA3PDPK1 | |
| Phenanthridine SCHEMBL30914262 | 0.76 | GPR3 (1.00) | GPR3KDM4ETOP2AADORA3PDPK1 | |
| Phenanthridine SCHEMBL9106884 | 0.76 | GPR3 (1.00) | GPR3KDM4ETOP2AADORA3PDPK1 | |
| SCHEMBL5576840 | 0.76 | KDM4E (0.61) | GPR3KDM4ETOP2ACYP1A2CYP3A4 | |
| SCHEMBL31062000 | 0.76 | KDM4E (0.54) | GPR3KDM4ETOP2AADORA3CYP1A2 | |
| SCHEMBL2045742 | 0.74 | MAPT (0.61) | KDM4ECYP1A2CYP3A4SMN1; SMN2ERN1 | |
| Phenanthridine SCHEMBL7108915 | 0.74 | GPR3 (0.77) | GPR3KDM4ETOP2AADORA3PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103254108-B | Preparation method of multifunctional pyrrole and pyrrolo [3,4-C ] quinoline | UNIV SOOCHOW | 2015-06-10 | — | — | CN | claimed |
| CN-103254108-A | New preparation method of multifunctional pyrrole and pyrrolo [3,4-C ] quinoline | UNIV SOOCHOW | 2013-08-21 | — | — | CN | claimed |
| EP-1773833-A4 | PYRROLO(OXO)QUINOLINES AS 5HT LIGANDS | BRISTOL MYERS SQUIBB CO (US) | 2009-07-22 | — | — | EP | claimed |
| EP-1773833-A2 | PYRROLO(OXO)QUINOLINES AS 5HT LIGANDS | Bristol-Myers Squibb Company (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006019940-A2 | PYRROLO(OXO)QUINOLINES AS 5HT LIGANDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-02-23 | — | — | WO | claimed |
| CN-114716438-B | Benzo [7,8] indolizine [1,2-c ] quinoline skeleton derivative and synthetic method thereof | 常州大学 | 2023-05-23 | — | — | CN | disclosed |
| CN-114716438-A | Derivative with benzo [7,8] indolizine [1,2-c ] quinoline skeleton and synthetic method thereof | 常州大学 | 2022-07-08 | — | — | CN | disclosed |
| EP-2590967-B1 | USE OF DIBENZOFURANS AND DIBENZOTHIOPHENES SUBSTITUTED BY NITROGEN-BONDED FIVE-MEMBERED HETEROCYCLIC RINGS IN ORGANIC ELECTRONICS | UDC IRELAND LTD (IE) | 2019-05-15 | — | — | EP | disclosed |
| CN-103254108-B | Preparation method of multifunctional pyrrole and pyrrolo [3,4-C ] quinoline | UNIV SOOCHOW | 2015-06-10 | — | — | CN | disclosed |
| US-8686147-B2 | Compound with serotoninergic activity, process for preparing it and pharmaceutical composition comprising it | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2014-04-01 | — | — | US | disclosed |
| CN-102099358-B | Compound with serotoninergic activity, process for preparing same and pharmaceutical composition comprising same | ACRAF | 2014-01-22 | — | — | CN | disclosed |
| CN-102099358-B | Compound with serotoninergic activity, process for preparing same and pharmaceutical composition comprising same | ACRAF | 2014-01-22 | — | — | CN | disclosed |
| WO-2010012611-A1 | COMPOUND WITH SEROTONINERGIC ACTIVITY, PROCESS FOR PREPARING IT AND PHARMACEUTICAL COMPOSITION COMPRISING IT | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2010-02-04 | — | — | WO | disclosed |
| EP-1773833-A4 | PYRROLO(OXO)QUINOLINES AS 5HT LIGANDS | BRISTOL MYERS SQUIBB CO (US) | 2009-07-22 | — | — | EP | disclosed |
| EP-1773833-A2 | PYRROLO(OXO)QUINOLINES AS 5HT LIGANDS | Bristol-Myers Squibb Company (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006019940-A2 | PYRROLO(OXO)QUINOLINES AS 5HT LIGANDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-02-23 | — | — | WO | disclosed |
| CN-1083477-A | 4-imino-quinoline, its preparation method and application thereof | HOECHST AG (DE) | 1994-03-09 | — | — | CN | disclosed |
| US-4440768-A | ANTIPSYCHOTIC, ANALGESIC AND ANTIDEPRESSANT AGENTS | ICI AMERICAS INC. (US) | 1984-04-03 | — | — | US | disclosed |
| EP-0029286-A1 | Pyrrolo(3,4-c)quinoline derivatives, processes therefor, and pharmaceutical compositions | ICI AMERICAS INC. (US) | 1981-05-27 | — | — | EP | disclosed |
| US-4268513-A | ANALGESICS, ANTIDEPRESSANTS, ANTIPSYCHOTICS | ICI AMERICAS INC. (US) | 1981-05-19 | — | — | US | disclosed |