Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8474031 | 0.82 | CA2 (0.41) | HSD17B10TP53CA2CA12CA1 | |
| SCHEMBL8339238 | 0.81 | HPGD (0.50) | HPGDALDH1A1RECQLHSD17B10TP53 | |
| Sulfuric Acid SCHEMBL16207785 | 0.79 | ALDH1A1 (0.81) | HPGDALDH1A1RECQLHSD17B10TP53 | |
| SCHEMBL24140260 | 0.79 | HPGD (0.47) | HPGDALDH1A1RECQLHSD17B10TP53 | |
| SCHEMBL14355361 | 0.79 | ALDH1A1 (0.41) | HPGDALDH1A1RECQLHSD17B10TP53 | |
| Hydrochloric Acid SCHEMBL5893987 | 0.78 | CA2 (0.53) | HPGDALDH1A1RECQLHSD17B10TP53 | |
| Phenylmethanesulfonic Acid SCHEMBL8373025 | 0.77 | CA2 (0.55) | HPGDALDH1A1HSD17B10CYP3A4CA2 | |
| SCHEMBL9294357 | 0.76 | ATM (0.62) | HPGDALDH1A1TP53CYP3A4CA2 | |
| SCHEMBL1309214 | 0.76 | CA2 (0.50) | HPGDALDH1A1TP53CA2SMN1; SMN2 | |
| SCHEMBL394806 | 0.76 | KMT2A (0.53) | ALDH1A1RECQLCA2CA1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119118882-A | Olatinib intermediate and preparation method thereof and preparation method of Olatinib | 浙江荣耀生物科技股份有限公司 | 2024-12-13 | — | — | CN | claimed |
| CN-108699072-B | Process for the preparation of 7H-pyrrolo [2,3-D ] pyrimidine compounds | 硕腾服务有限责任公司 | 2021-02-26 | — | — | CN | claimed |
| EP-3416965-B1 | PROCESS FOR PREPARING 7H-PYRROLO [2,3-D]PYRIMIDINE COMPOUNDS | ZOETIS SERVICES LLC (US) | 2020-10-07 | — | — | EP | claimed |
| EP-3416965-A1 | PROCESS FOR PREPARING 7H-PYRROLO [2, 3-D]PYRIMIDINE COMPOUNDS | Zoetis Services LLC (US) | 2018-12-26 | — | — | EP | claimed |
| CN-108699072-A | Process for the preparation of 7H-pyrrolo [2,3-D ] pyrimidine compounds | 硕腾服务有限责任公司 | 2018-10-23 | — | — | CN | claimed |
| US-9926327-B2 | Process for preparing 7H-pyrrolo[2,3-D]pyrimidine compounds | ZOETIS SERVICES LLC (US) | 2018-03-27 | — | — | US | claimed |
| WO-2017142740-A1 | PROCESS FOR PREPARING 7H-PYRROLO [2, 3-D] PYRIMIDINE COMPOUNDS | ZOETIS SERVICES LLC (US) | 2017-08-24 | — | — | WO | claimed |
| US-20170233397-A1 | PROCESS FOR PREPARING 7H-PYRROLO[2,3-D]PYRIMIDINE COMPOUNDS | ZOETIS SERVICES LLC | 2017-08-17 | — | — | US | claimed |
| CN-119118882-A | Olatinib intermediate and preparation method thereof and preparation method of Olatinib | 浙江荣耀生物科技股份有限公司 | 2024-12-13 | — | — | CN | disclosed |
| CN-119118882-A | Olatinib intermediate and preparation method thereof and preparation method of Olatinib | 浙江荣耀生物科技股份有限公司 | 2024-12-13 | — | — | CN | disclosed |
| CN-117756810-A | Preparation method of trans-7H-pyrrolo [2,3-d ] pyrimidine compound | 苏州莱安医药化学技术有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-112279854-B | Preparation method of 7H-pyrrolo [2,3-d ] pyrimidine compound | 常州齐晖药业有限公司 | 2022-04-05 | — | — | CN | disclosed |
| CN-111909156-B | Preparation method of olatinib maleate | 常州齐晖药业有限公司 | 2022-04-05 | — | — | CN | disclosed |
| CN-108699072-B | Process for the preparation of 7H-pyrrolo [2,3-D ] pyrimidine compounds | 硕腾服务有限责任公司 | 2021-02-26 | — | — | CN | disclosed |
| US-9926327-B2 | Process for preparing 7H-pyrrolo[2,3-D]pyrimidine compounds | ZOETIS SERVICES LLC (US) | 2018-03-27 | — | — | US | disclosed |
| WO-2017142740-A1 | PROCESS FOR PREPARING 7H-PYRROLO [2, 3-D] PYRIMIDINE COMPOUNDS | ZOETIS SERVICES LLC (US) | 2017-08-24 | — | — | WO | disclosed |
| WO-2017142740-A1 | PROCESS FOR PREPARING 7H-PYRROLO [2, 3-D] PYRIMIDINE COMPOUNDS | ZOETIS SERVICES LLC (US) | 2017-08-24 | — | — | WO | disclosed |
| US-20170233397-A1 | PROCESS FOR PREPARING 7H-PYRROLO[2,3-D]PYRIMIDINE COMPOUNDS | ZOETIS SERVICES LLC | 2017-08-17 | — | — | US | disclosed |
| US-20170233397-A1 | PROCESS FOR PREPARING 7H-PYRROLO[2,3-D]PYRIMIDINE COMPOUNDS | ZOETIS SERVICES LLC | 2017-08-17 | — | — | US | disclosed |
| US-20170233397-A1 | PROCESS FOR PREPARING 7H-PYRROLO[2,3-D]PYRIMIDINE COMPOUNDS | ZOETIS SERVICES LLC | 2017-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170233397-A1 | PROCESS FOR PREPARING 7H-PYRROLO[2,3-D]PYRIMIDINE COMPOUNDS | TPMT, TYMS, TYMP | HPGD 571/4885ALDH1A1 1734/4885RECQL 1821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.