SCHEMBL1920654

SCHEMBL1920654

Clc1ccccc1C#Cc1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.57
APP P05067 1/20 0.57
MAPT P10636 3/20 0.56
NPC1 O15118 2/20 0.56
MEN1 O00255 2/20 0.56
ALDH1A1 P00352 2/20 0.56
CYP1A2 P05177 2/20 0.56
CYP3A4 P08684 2/20 0.56
CYP2C9 P11712 2/20 0.56
HPGD P15428 2/20 0.56
CYP2C19 P33261 2/20 0.56
KMT2A Q03164 2/20 0.56
HSD17B10 Q99714 2/20 0.56
KDM4E B2RXH2 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
KCNH2 Q12809 1/20 0.52
PTGDR2 Q9Y5Y4 5/20 0.47
GRM5 P41594 3/20 0.47
CA12 O43570 1/20 0.47
CA2 P00918 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31279173 1.00 FFAR1 (0.57) FFAR1APPMAPTNPC1MEN1
SCHEMBL30707788 0.87 KCNH2 (0.61) FFAR1ALDH1A1CYP1A2KCNH2PTGDR2
SCHEMBL4448140 0.87 KCNH2 (0.61) FFAR1ALDH1A1CYP1A2KCNH2PTGDR2
SCHEMBL23639130 0.83 MAPT (0.48) FFAR1APPMAPTNPC1MEN1
SCHEMBL2114742 0.82 APP (0.75) FFAR1APPMAPTNPC1MEN1
SCHEMBL5871989 0.82 APP (0.75) FFAR1APPMAPTNPC1MEN1
SCHEMBL1921623 0.78 APP (0.52) FFAR1APPMAPTKMT2AKCNH2
SCHEMBL3835808 0.78 CYP2A6 (0.49) CYP1A2CYP3A4CYP2C9CYP2C19PTGDR2
SCHEMBL1921328 0.78 PTGDR2 (0.49) FFAR1MAPTNPC1MEN1ALDH1A1
SCHEMBL17104741 0.78 ADK (0.49) FFAR1APPMAPTALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117625071-A Light conversion adhesive film, preparation method thereof and perovskite battery packaging structure 广东明阳薄膜科技有限公司 2024-03-01 CN claimed
US-5194178-A Liquid Crystals MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1993-03-16 US claimed
JP-4210931-A None JP disclosed
JP-4210931-A None JP disclosed
CN-117625071-A Light conversion adhesive film, preparation method thereof and perovskite battery packaging structure 广东明阳薄膜科技有限公司 2024-03-01 CN disclosed
CN-111686817-B Copper-supported catalyst, preparation method and application thereof 上海博腾智拓医药科技有限公司 2024-02-09 CN disclosed
CN-108430980-B Microbicidal oxadiazole derivatives 先正达参股股份有限公司 2022-09-02 CN disclosed
WO-2021056466-A1 METHOD FOR PREPARING SECONDARY AROMATIC AMINE 广东石油化工学院 2021-04-01 WO disclosed
WO-2021056466-A1 METHOD FOR PREPARING SECONDARY AROMATIC AMINE 广东石油化工学院 2021-04-01 WO disclosed
CN-112574042-A Process for preparing secondary aromatic amines 广东石油化工学院 2021-03-30 CN disclosed
CN-111686817-A Copper-supported catalyst, preparation method and application thereof 凯惠药业(上海)有限公司 2020-09-22 CN disclosed
US-20100168429-A1 Transition metal catalyzed synthesis of N-aminoindoles SANOFI-AVENTIS (FR) 2010-07-01 US disclosed
EP-2170833-A1 A TRANSITION METAL CATALYZED SYNTHESIS OF 2H-INDAZOLES Sanofi-Aventis (FR) 2010-04-07 EP disclosed
EP-2134682-A1 A TRANSITION METAL CATALYZED SYNTHESIS OF N-AMINOINDOLES Sanofi-Aventis (FR) 2009-12-23 EP disclosed
WO-2009003589-A1 A PROCESS FOR THE PALLADIUM-CATALYZED COUPLING OF TERMINAL ALKYNES WITH ARYL TOSYLATES SANOFI-AVENTIS (FR) 2009-01-08 WO disclosed
WO-2009000411-A1 A TRANSITION METAL CATALYZED SYNTHESIS OF 2H-INDAZOLES SANOFI-AVENTIS (FR) 2008-12-31 WO disclosed
WO-2008125207-A1 A TRANSITION METAL CATALYZED SYNTHESIS OF N-AMINOINDOLES SANOFI-AVENTIS (FR) 2008-10-23 WO disclosed
US-5194178-A Liquid Crystals MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1993-03-16 US disclosed
JP-H04210931-A CHLORO TOLANE MERCK PATENT GMBH 1992-08-03 JP disclosed
JP-H04210931-A CHLORO TOLANE MERCK PATENT GMBH 1992-08-03 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100168429-A1 Transition metal catalyzed synthesis of N-aminoindoles NAT1, H1-3, H1-2 FFAR1 2731/4885APP 3821/4885MAPT 2698/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.