Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 2/20 | 0.60 |
| ▸ | TUBB | P07437 | 2/20 | 0.60 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.60 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.60 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.60 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.60 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.60 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.60 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.60 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.60 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.60 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.60 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.60 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.60 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.60 |
| ▸ | IDO1 | P14902 | 2/20 | 0.55 |
| ▸ | GFER | P55789 | 2/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | STAT3 | P40763 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29940756 | 1.00 | TUBB4A (0.60) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9328490 | 0.82 | TUBB4A (0.64) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5307941 | 0.82 | TUBB4A (0.77) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL24191196 | 0.78 | TUBB4A (0.60) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL11382070 | 0.78 | STAT3 (0.58) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL30897295 | 0.78 | STAT3 (0.58) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4068600 | 0.75 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9161820 | 0.75 | IDO1 (0.60) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL34463637 | 0.74 | TUBB4A (0.96) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL5731230 | 0.74 | TUBB4A (0.54) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109942478-B | Synthetic method of 3-methylthio indole derivative | 南京理工大学 | 2022-07-22 | — | — | CN | claimed |
| CN-109942478-A | A kind of synthetic method of 3- methylthioindole analog derivative | 南京理工大学 | 2019-06-28 | — | — | CN | claimed |
| CN-106674081-A | Synthetic method of 3-methylthio indole derivative | 南京理工大学 | 2017-05-17 | — | — | CN | claimed |
| US-3992392-A | Synthesis of indoles from anilines and intermediates therein | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1976-11-16 | — | — | US | claimed |
| US-20240208967-A1 | Pyrimidine or Pyridine Compounds, Preparation Method Therefor and Pharmaceutical Uses Thereof | INVENTISBIO CO LTD (CN) | 2024-06-27 | — | — | US | disclosed |
| CN-117298319-A | Novel material with deodorizing, antibacterial and bacteriostatic properties and processing technology thereof | 易维(佛山)科技有限公司 | 2023-12-29 | — | — | CN | disclosed |
| CN-109942478-B | Synthetic method of 3-methylthio indole derivative | 南京理工大学 | 2022-07-22 | — | — | CN | disclosed |
| CN-109942478-B | Synthetic method of 3-methylthio indole derivative | 南京理工大学 | 2022-07-22 | — | — | CN | disclosed |
| CN-109942478-B | Synthetic method of 3-methylthio indole derivative | 南京理工大学 | 2022-07-22 | — | — | CN | disclosed |
| WO-2022061008-A2 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-03-24 | — | — | WO | disclosed |
| US-11203589-B2 | Pyrimidine or pyridine compounds, preparation method therefor and pharmaceutical uses thereof | InventisBio Co., Ltd. (CN) | 2021-12-21 | — | — | US | disclosed |
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |
| US-5684034-A | INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE | ELI LILLY AND COMPANY (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0620215-A1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |
| US-4654360-A | 1,2,3-trisubstituted indoles for treatment of inflammation | SYNTEX (U.S.A.) INC. (US) | 1987-03-31 | — | — | US | disclosed |
| EP-0035259-A1 | Tetrahydrothiopyrano(3,2-b)indole derivatives, process for their preparation and pharmaceutical composition containing these compounds | SHIONOGI & CO., LTD. (JP) | 1981-09-09 | — | — | EP | disclosed |
| US-4101583-A | Alpha-methylthio-alpha-(2-aminophenyl) acetaldehyde diloweralkyl acetals | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1978-07-18 | — | — | US | disclosed |
| US-4080341-A | Carbazolenine and indole compounds | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1978-03-21 | — | — | US | disclosed |
| US-4067875-A | Certain N-phenyl or N-pyridyl aza sulfonium salts | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1978-01-10 | — | — | US | disclosed |
| US-3992392-A | Synthesis of indoles from anilines and intermediates therein | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1976-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240208967-A1 | Pyrimidine or Pyridine Compounds, Preparation Method Therefor and Pharmaceutical Uses Thereof | EGFR, WEE1, DPYD | TUBB4A 4423/4885TUBB 4256/4885TUBA3C 4581/4885 |
| US-11203589-B2 | Pyrimidine or pyridine compounds, preparation method therefor and pharmaceutical uses thereof | EGFR, WEE1, TP53 | TUBB4A 4085/4885TUBB 4028/4885TUBA3C 4652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.