Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA4 | P22748 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CA6 | P23280 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712689 | 0.86 | ALOX5 (0.44) | ALDH1A1MAPK1ALOX5CA12CA1 | |
| Water SCHEMBL9085223 | 0.85 | ALOX5 (0.43) | ALDH1A1MAPK1ALOX5CA12CA1 | |
| SCHEMBL5586033 | 0.85 | TSHR (0.49) | ALDH1A1KDM4ETSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL10700887 | 0.85 | ALOX5 (0.43) | ALDH1A1MAPK1ALOX5CA12CA1 | |
| SCHEMBL28747754 | 0.81 | ALOX5 (0.40) | ALDH1A1MAPK1ALOX5CA12CA1 | |
| Water SCHEMBL28231965 | 0.77 | ALOX5 (0.38) | ALDH1A1MAPK1ALOX5KDM4EPOLB | |
| SCHEMBL18770551 | 0.76 | MKNK1 (0.41) | CA12CA1CA2CA9CA14 | |
| Bicarbonate SCHEMBL28655831 | 0.73 | MEN1 (0.33) | ALDH1A1ALOX5KDM4EPOLBGAA | |
| SCHEMBL10509467 | 0.71 | KDM4E (0.41) | ALDH1A1CA12CA9KDM4EPOLB | |
| SCHEMBL9995986 | 0.71 | TSHR (0.45) | ALDH1A1ALOX5KDM4ETSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3411080-A2 | COMPOUNDS AND METHODS OF TREATING RNA-MEDIATED DISEASES | Arrakis Therapeutics, Inc. (US) | 2018-12-12 | — | — | EP | disclosed |
| CN-108778345-A | Compounds and methods for treating RNA-mediated diseases | 阿拉基斯医疗公司 | 2018-11-09 | — | — | CN | disclosed |
| WO-2018030550-A1 | HETEROCYCLIC COMPOUNDS WITH AN ROR(GAMMA)T MODULATING ACTIVITY | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-02-15 | — | — | WO | disclosed |
| WO-2017136450-A2 | COMPOUNDS AND METHODS OF TREATING RNA-MEDIATED DISEASES | ARRAKIS THERAPEUTICS, INC. (US) | 2017-08-10 | — | — | WO | disclosed |