Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL6652912 | 0.93 | TSHR (0.34) | MEN1KMT2APOLBCASP6CYP2C9 | |
| SCHEMBL3201327 | 0.92 | MAPT (0.36) | MEN1KMT2AMAPTGAAHTR2C | |
| Benzene SCHEMBL28211936 | 0.92 | MAPT (0.36) | MEN1KMT2AMAPTGAAHTR2C | |
| Acetone SCHEMBL25211182 | 0.91 | GAA (0.33) | MEN1KMT2AMAPTGAAHTR2C | |
| Urea SCHEMBL28100950 | 0.91 | TSHR (0.35) | MEN1KMT2APOLBCYP2C9MAPT | |
| SCHEMBL3662203 | 0.90 | MAPT (0.37) | MEN1KMT2AMAPTGAAHTR2C | |
| SCHEMBL8924 | 0.90 | MAPT (0.37) | MEN1KMT2AMAPTGAAHTR2C | |
| SCHEMBL16341187 | 0.90 | MAPT (0.37) | MEN1KMT2AMAPTGAAHTR2C | |
| SCHEMBL29804885 | 0.90 | MAPT (0.37) | MEN1KMT2AMAPTGAAHTR2C | |
| Benzophenone SCHEMBL16161312 | 0.90 | ALDH1A1 (0.47) | MEN1KMT2AP2RX4MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113637151-B | Preparation method of polybenzoxazine carbonate | 安徽大学 | 2022-06-03 | — | — | CN | claimed |
| CN-113637151-A | Preparation method of novel polybenzoxazine carbonate | 安徽大学 | 2021-11-12 | — | — | CN | claimed |
| CN-113637151-B | Preparation method of polybenzoxazine carbonate | 安徽大学 | 2022-06-03 | — | — | CN | disclosed |
| CN-113637151-B | Preparation method of polybenzoxazine carbonate | 安徽大学 | 2022-06-03 | — | — | CN | disclosed |
| CN-113637151-B | Preparation method of polybenzoxazine carbonate | 安徽大学 | 2022-06-03 | — | — | CN | disclosed |
| CN-113637151-A | Preparation method of novel polybenzoxazine carbonate | 安徽大学 | 2021-11-12 | — | — | CN | disclosed |
| CN-113637151-A | Preparation method of novel polybenzoxazine carbonate | 安徽大学 | 2021-11-12 | — | — | CN | disclosed |
| CN-113637151-A | Preparation method of novel polybenzoxazine carbonate | 安徽大学 | 2021-11-12 | — | — | CN | disclosed |