Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.57 |
| ▸ | GCK | P35557 | 15/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1920749 | 0.89 | GRAMD1A (0.55) | GRAMD1AGCKHDAC1HDAC6KDM4E | |
| SCHEMBL1919616 | 0.86 | GRAMD1A (0.55) | GRAMD1AGCKHDAC1KDM4EMAPT | |
| SCHEMBL2699931 | 0.79 | GRAMD1A (0.51) | GRAMD1AGCKKDM4EMAPT | |
| SCHEMBL3354933 | 0.77 | GRAMD1A (0.42) | GRAMD1AGCKHDAC1HDAC6KDM4E | |
| SCHEMBL198643 | 0.76 | GRAMD1A (0.53) | GRAMD1AGCKHDAC1KDM4EMAPT | |
| SCHEMBL1919143 | 0.75 | HDAC2 (0.44) | GRAMD1AGCKHDAC1HDAC6KDM4E | |
| SCHEMBL165650 | 0.73 | GRAMD1A (0.53) | GRAMD1AGCKKDM4EMAPTMKNK1 | |
| SCHEMBL29726004 | 0.73 | GRAMD1A (1.00) | GRAMD1AGCK | |
| SCHEMBL172106 | 0.72 | ADORA1 (0.56) | GRAMD1AGCKKDM4EMAPTMKNK1 | |
| SCHEMBL1920008 | 0.71 | HDAC1 (0.43) | GRAMD1AHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011529504-A | — | — | 2011-12-08 | — | — | JP | claimed |
| EP-2326622-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE HISTONE DEACETYLASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2011-06-01 | — | — | EP | claimed |
| WO-2010014611-A1 | CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE HISTONE DEACETYLASE INHIBITOR COMPOUNDS | GILEAD COLORADO, INC. (US) | 2010-02-04 | — | — | WO | claimed |