Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 5/20 | 0.49 |
| ▸ | PYGM | P11217 | 5/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 12/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4232147 | 0.84 | PYGL (0.66) | PYGLPYGMRIPK1 | |
| SCHEMBL4216634 | 0.84 | PYGL (0.66) | PYGLPYGMRIPK1 | |
| SCHEMBL1976547 | 0.84 | PYGL (0.66) | PYGLPYGMRIPK1 | |
| SCHEMBL19207722 | 0.81 | CA1 (0.47) | RIPK1 | |
| SCHEMBL1977227 | 0.81 | CA1 (0.47) | RIPK1 | |
| SCHEMBL1975329 | 0.81 | CA1 (0.47) | RIPK1 | |
| SCHEMBL8880599 | 0.80 | RIPK1 (0.43) | PYGLPYGMRIPK1 | |
| SCHEMBL19805459 | 0.79 | PYGL (0.41) | PYGLPYGMRIPK1NPC1MAPK13 | |
| SCHEMBL22469203 | 0.76 | PYGL (0.57) | PYGLPYGMRIPK1 | |
| SCHEMBL26167122 | 0.76 | PYGL (0.38) | PYGLPYGMRIPK1NPC1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414239-A2 | INHIBITORS OF RECEPTOR-INTERACTING PROTEIN KINASE 1 | Denali Therapeutics Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017136727-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-08-10 | — | — | WO | disclosed |