Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | PTPRB | P23467 | 1/20 | 0.47 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.39 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.39 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.39 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20586742 | 1.00 | CCR3 (0.47) | CCR3PTPRBSOAT1LMNANPC1 | |
| SCHEMBL19257971 | 0.82 | PTPRB (0.49) | CCR3PTPRBLMNARAB9APKM | |
| SCHEMBL772012 | 0.81 | PTPRB (0.52) | CCR3PTPRBNPC1RAB9ACTSA | |
| SCHEMBL772011 | 0.81 | PTPRB (0.52) | CCR3PTPRBNPC1RAB9ACTSA | |
| SCHEMBL22267911 | 0.81 | CCR3 (0.39) | CCR3PTPRBSOAT1LMNANPC1 | |
| SCHEMBL19257745 | 0.81 | CCR3 (0.39) | CCR3PTPRBSOAT1LMNANPC1 | |
| SCHEMBL22267912 | 0.78 | ADRB3 (0.39) | CCR3PTPRBSOAT1LMNANPC1 | |
| SCHEMBL22267910 | 0.76 | CCR3 (0.36) | CCR3PTPRBSOAT1LMNANPC1 | |
| SCHEMBL19257973 | 0.74 | RAD52 (0.46) | CCR3PTPRBLMNANPC1RAB9A | |
| SCHEMBL20962839 | 0.73 | ACACB (0.42) | CCR3PTPRBSOAT1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10723727-B2 | Tubulysin analogs and methods for their preparation | PFIZER INC. (US) | 2020-07-28 | — | — | US | disclosed |
| US-20180362519-A1 | TUBULYSIN ANALOGS AND METHODS FOR THEIR PREPARATION | PFIZER INC. (US) | 2018-12-20 | — | — | US | disclosed |
| EP-3411371-A1 | TUBULYSIN ANALOGS AND METHODS FOR THEIR PREPARATION | Pfizer Inc (US) | 2018-12-12 | — | — | EP | disclosed |
| WO-2017134547-A1 | TUBULYSIN ANALOGS AND METHODS FOR THEIR PREPARATION | PFIZER INC. (US) | 2017-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180362519-A1 | TUBULYSIN ANALOGS AND METHODS FOR THEIR PREPARATION | NGLY1, TEK, TEKT1 | CCR3 913/4885PTPRB 794/4885SOAT1 4368/4885 |
| US-10723727-B2 | Tubulysin analogs and methods for their preparation | NGLY1, TEK, TEKT1 | CCR3 913/4885PTPRB 794/4885SOAT1 4368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.