Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CDK8 | P49336 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14840736 | 0.85 | MAPK14 (0.40) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL2076094 | 0.81 | RECQL (0.53) | ALDH1A1SMN1; SMN2CDK8CSF1RFGFR1 | |
| SCHEMBL29954023 | 0.81 | CSF1R (0.42) | ALDH1A1SMN1; SMN2CDK8CSF1RFGFR1 | |
| SCHEMBL13055593 | 0.81 | CDK8 (0.49) | ALDH1A1SMN1; SMN2CDK8CSF1RFGFR1 | |
| SCHEMBL7915882 | 0.80 | MEN1 (0.59) | ALDH1A1SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL6782113 | 0.76 | SMN1; SMN2 (0.61) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL19209467 | 0.76 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2CDK8NPC1RAB9A | |
| SCHEMBL14996608 | 0.76 | MAPT (0.47) | ALDH1A1SMN1; SMN2CDK8NPC1RAB9A | |
| SCHEMBL17055637 | 0.74 | MAPT (0.46) | ALDH1A1SMN1; SMN2CDK8NPC1RAB9A | |
| SCHEMBL9201586 | 0.73 | CDK8 (0.44) | ALDH1A1SMN1; SMN2CDK8CSF1RFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3411375-B1 | PYRAZOLE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2020-08-05 | — | — | EP | disclosed |
| EP-3411375-B1 | PYRAZOLE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2020-08-05 | — | — | EP | disclosed |
| US-10189844-B2 | Pyrazole derivatives as phosphoinositide 3-kinases inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2019-01-29 | — | — | US | disclosed |
| US-10189844-B2 | Pyrazole derivatives as phosphoinositide 3-kinases inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2019-01-29 | — | — | US | disclosed |
| EP-3411375-A1 | PYRAZOLE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2018-12-12 | — | — | EP | disclosed |
| WO-2017134053-A1 | PYRAZOLE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-08-10 | — | — | WO | disclosed |
| WO-2017134053-A1 | PYRAZOLE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-08-10 | — | — | WO | disclosed |
| US-20170226109-A1 | PYRAZOLE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-08-10 | — | — | US | disclosed |
| US-20170226109-A1 | PYRAZOLE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-08-10 | — | — | US | disclosed |
| US-20170226109-A1 | PYRAZOLE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10189844-B2 | Pyrazole derivatives as phosphoinositide 3-kinases inhibitors | PI4KA, PI4KB, PI4K2B | ALDH1A1 3454/4885SMN1; SMN2 3039/4885CDK8 396/4885 |
| US-20170226109-A1 | PYRAZOLE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | PI4KA, PI4KB, PI4K2B | ALDH1A1 3454/4885SMN1; SMN2 3039/4885CDK8 396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.