Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK6 | Q00534 | 18/20 | 0.69 |
| ▸ | CCND1 | P24385 | 13/20 | 0.69 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.62 |
| ▸ | CDK4 | P11802 | 4/20 | 0.60 |
| ▸ | CCND3 | P30281 | 4/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.60 |
| ▸ | CDK2 | P24941 | 2/20 | 0.60 |
| ▸ | PIM1 | P11309 | 2/20 | 0.60 |
| ▸ | CIT | O14578 | 1/20 | 0.60 |
| ▸ | GAK | O14976 | 1/20 | 0.60 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.60 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.60 |
| ▸ | STK16 | O75716 | 1/20 | 0.60 |
| ▸ | CCNK | O75909 | 1/20 | 0.60 |
| ▸ | STK10 | O94804 | 1/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19231733 | 0.93 | CDK6 (0.62) | CDK6CCND1DYRK2CDK4CCND3 | |
| SCHEMBL19231737 | 0.92 | CDK6 (0.64) | CDK6CCND1DYRK2CDK2PIM1 | |
| SCHEMBL19209819 | 0.91 | CDK6 (0.57) | CDK6CCND1DYRK2CDK4CCND3 | |
| SCHEMBL17489238 | 0.90 | CDK6 (0.74) | CDK6CCND1DYRK2CDK4CCND3 | |
| SCHEMBL17477168 | 0.90 | CDK6 (0.75) | CDK6CCND1DYRK2CDK4CCND3 | |
| SCHEMBL19231824 | 0.90 | CDK6 (0.62) | CDK6CCND1DYRK2PIM1 | |
| SCHEMBL19231730 | 0.87 | CDK6 (0.53) | CDK6CCND1DYRK2CDK4CCND3 | |
| SCHEMBL19231735 | 0.86 | CDK6 (0.53) | CDK6CCND1DYRK2CDK4CCND3 | |
| SCHEMBL19231732 | 0.86 | CDK6 (0.56) | CDK6CCND1DYRK2CDK4CDK2 | |
| SCHEMBL19966302 | 0.86 | CDK6 (0.66) | CDK6CCND1DYRK2CDK4CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017133701-A1 | CERTAIN PROTEIN KINASE INHIBITORS | SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) | 2017-08-10 | — | — | WO | claimed |
| CN-108602799-B | Kinase inhibitor | 上海复尚慧创医药研究有限公司 | 2021-08-03 | — | — | CN | disclosed |
| WO-2017133701-A1 | CERTAIN PROTEIN KINASE INHIBITORS | SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) | 2017-08-10 | — | — | WO | disclosed |
| WO-2017133701-A1 | CERTAIN PROTEIN KINASE INHIBITORS | SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) | 2017-08-10 | — | — | WO | disclosed |
| US-9169438-B2 | Compounds of liquid crystalline medium and use thereof for high-frequency components | MERCK PATENT GMBH (DE) | 2015-10-27 | — | — | US | disclosed |