Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18280698 | 0.87 | EPHX1 (0.45) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL4312363 | 0.87 | EPHX1 (0.47) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL584085 | 0.85 | EPHX1 (0.46) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL28953820 | 0.85 | EPHX1 (0.54) | EPHX1TRPM8TRPA1TRPV1CYP19A1 | |
| SCHEMBL120127 | 0.84 | EPHX1 (0.45) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL8743483 | 0.83 | EPHX1 (0.50) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL38660082 | 0.83 | EPHX1 (0.50) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL15468048 | 0.83 | EPHX1 (0.44) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL583665 | 0.83 | EPHX1 (0.44) | EPHX1TRPM8TRPA1KCNA5TRPV1 | |
| SCHEMBL4314193 | 0.81 | EPHX1 (0.43) | EPHX1TRPM8TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3411045-A1 | CHEMICALS AND METHODS TO PREVENT AND TREAT TGF-BETA MEDIATED ACTIVATION OF FIBROBLASTS TO REDUCE AND TREAT CANCER AND FIBROSIS | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (US) | 2018-12-12 | — | — | EP | claimed |
| WO-2017136515-A1 | CHEMICALS AND METHODS TO PREVENT AND TREAT TGF-BETA MEDIATED ACTIVATION OF FIBROBLASTS TO REDUCE AND TREAT CANCER AND FIBROSIS | CARDELLI JAMES ALLEN (US) | 2017-08-10 | — | — | WO | claimed |
| EP-3411045-A1 | CHEMICALS AND METHODS TO PREVENT AND TREAT TGF-BETA MEDIATED ACTIVATION OF FIBROBLASTS TO REDUCE AND TREAT CANCER AND FIBROSIS | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College (US) | 2018-12-12 | — | — | EP | disclosed |
| WO-2017136515-A1 | CHEMICALS AND METHODS TO PREVENT AND TREAT TGF-BETA MEDIATED ACTIVATION OF FIBROBLASTS TO REDUCE AND TREAT CANCER AND FIBROSIS | CARDELLI JAMES ALLEN (US) | 2017-08-10 | — | — | WO | disclosed |