Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19211220 | 0.84 | TNKS2 (0.44) | NPC1ALDH1A1MEN1KMT2ATNKS2 | |
| SCHEMBL19211223 | 0.83 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2ATNKS2KDM4E | |
| Benzene SCHEMBL28794130 | 0.77 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL20667102 | 0.76 | ADORA2A (0.53) | NPC1JAK2MEN1KMT2AGLO1 | |
| SCHEMBL19211173 | 0.75 | RHEB (0.53) | NPC1KMT2ARAB9A | |
| SCHEMBL10031 | 0.74 | ALDH1A1 (0.55) | ALDH1A1KMT2AKDM4ELMNAHPGD | |
| SCHEMBL12338439 | 0.74 | ALDH1A1 (0.65) | NR4A2ALDH1A1KMT2AKDM4EHPGD | |
| SCHEMBL28889107 | 0.74 | NPC1 (0.66) | NPC1NOTUMJAK2CASP3SENP7 | |
| SCHEMBL20657858 | 0.73 | ALDH1A1 (0.44) | NOTUMALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL1885355 | 0.73 | ALDH1A1 (0.71) | NPC1NR4A2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414229-A1 | QUINOLINONE LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | Pharmakea, Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139274-A1 | QUINOLINONE LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2017-08-17 | — | — | WO | disclosed |