SCHEMBL19211615

SCHEMBL19211615

CCOC(Cn1c(=O)ccc2ccc(OCCO)nc21)OCC

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PKM P14618 1/20 0.36
CDK4 P11802 13/20 0.34
CCND1 P24385 13/20 0.34
CCND2 P30279 13/20 0.34
CCND3 P30281 13/20 0.34
ADORA2A P29274 2/20 0.34
KDM4E B2RXH2 1/20 0.34
ADORA1 P30542 1/20 0.34
ALDH1A1 P00352 1/20 0.31
CCNB2 O95067 1/20 0.31
CCNE2 O96020 1/20 0.31
CDK1 P06493 1/20 0.31
FGFR1 P11362 1/20 0.31
SRC P12931 1/20 0.31
CCNB1 P14635 1/20 0.31
CCNA2 P20248 1/20 0.31
FGFR2 P21802 1/20 0.31
FGFR4 P22455 1/20 0.31
FGFR3 P22607 1/20 0.31
CCNE1 P24864 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19212793 0.85 MTNR1A (0.35) PKMCDK4CCND1CCND2CCND3
SCHEMBL19211564 0.84 MTNR1A (0.35) CDK4CCND1CCND2CCND3KDM4E
SCHEMBL19211571 0.77 PKM (0.40) PKMCDK4CCND1CCND2CCND3
SCHEMBL19212769 0.76 CDK4 (0.33) CDK4CCND1CCND2CCND3ADORA2A
SCHEMBL20710551 0.76 MAPK8 (0.46) CDK4CCND1CCND2CCND3CCNB2
SCHEMBL19231467 0.75 CDK4 (0.39) PKMCDK4CCND1CCND2CCND3
SCHEMBL19211604 0.75 MAPT (0.37) PKMCDK4CCND1CCND2CCND3
SCHEMBL19212759 0.74 CA1 (0.39) PKMCDK4CCND1CCND2CCND3
SCHEMBL19211574 0.73 CDK4 (0.44) CDK4CCND1CCND2CCND3ALDH1A1
SCHEMBL18544236 0.71 KCNH2 (0.40) CDK4CCND1CCND2CCND3KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3413976-A1 HETEROCYCLIC COMPOUNDS, IN PARTICULAR 2-OXO-4,4,5,5,6,6,7,7-OCTAHYDROBENZOXAZOLE DERIVATIVES, AND THEIR USE AS ANTIBACTERIAL COMPOUNDS Redx Pharma PLC (GB) 2018-12-19 EP disclosed
EP-3414246-A1 ANTIBACTERIAL COMPOUNDS Redx Pharma PLC (GB) 2018-12-19 EP disclosed
WO-2017137743-A1 ANTIBACTERIAL COMPOUNDS REDX PHARMA PLC (GB) 2017-08-17 WO disclosed
WO-2017137744-A1 HETEROCYCLIC COMPOUNDS, IN PARTICULAR 2-OXO-4,4,5,5,6,6,7,7-OCTAHYDROBENZOXAZOLE DERIVATIVES, AND THEIR USE AS ANTIBACTERIAL COMPOUNDS REDX PHARMA PLC (GB) 2017-08-17 WO disclosed