Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | GFER | P55789 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RORC | P51449 | 2/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 4/20 | 0.39 |
| ▸ | HTR1D | P28221 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22957459 | 0.83 | MAPT (0.51) | MAPTALDH1A1MAPK1HTTLMNA | |
| SCHEMBL19212196 | 0.80 | MAPT (0.44) | MAPTGAAGFERALDH1A1RORC | |
| SCHEMBL19212260 | 0.80 | MAPT (0.50) | MAPTGAAALDH1A1CNR1CNR2 | |
| SCHEMBL2021224 | 0.79 | MAPT (0.66) | MAPTGAAGFERALDH1A1CASP6 | |
| SCHEMBL28747907 | 0.79 | MAPT (0.50) | MAPTGAAGFERALDH1A1MAPK1 | |
| SCHEMBL11299225 | 0.79 | GAA (0.59) | MAPTGAAGFERALDH1A1CASP6 | |
| SCHEMBL15265036 | 0.77 | GRIN2B (0.51) | MAPTGFERALDH1A1LMNAKDM4E | |
| SCHEMBL19212275 | 0.77 | ADRB1 (0.61) | MAPTGAAHTTRAD52HTR1A | |
| SCHEMBL17801223 | 0.77 | MAPT (0.51) | MAPTGAAGFERALDH1A1CASP6 | |
| SCHEMBL19212222 | 0.77 | ME2 (0.50) | MAPTGAAGFERALDH1A1CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414252-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139778-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2017-08-17 | — | — | WO | disclosed |