Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19212409 | 0.89 | P2RY12 (0.57) | P2RY12 | |
| SCHEMBL21457818 | 0.87 | BACE1 (0.48) | MEN1KMT2AACHEKEAP1NFE2L2 | |
| SCHEMBL28680929 | 0.85 | P2RY12 (0.43) | P2RY12KEAP1NFE2L2 | |
| SCHEMBL31142982 | 0.82 | P2RY12 (0.61) | P2RY12 | |
| SCHEMBL19211083 | 0.81 | SMN1; SMN2 (0.52) | MEN1KMT2AACHEBACE1SLC2A1 | |
| SCHEMBL24969726 | 0.79 | P2RY12 (0.46) | P2RY12MEN1KMT2ATLR9TLR7 | |
| SCHEMBL28683499 | 0.79 | BACE1 (0.47) | MEN1KMT2AACHEBACE1SLC2A1 | |
| SCHEMBL28688740 | 0.79 | BACE1 (0.47) | MEN1KMT2AACHEKEAP1NFE2L2 | |
| SCHEMBL19212337 | 0.79 | MEN1 (0.51) | P2RY12MEN1KMT2AKITGPR119 | |
| SCHEMBL31142973 | 0.78 | P2RY12 (0.46) | P2RY12MEN1KMT2AKITGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414252-B1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | VALO HEALTH INC (US) | 2022-07-06 | — | — | EP | disclosed |
| CN-109071560-B | Thienopyridine carboxamides as ubiquitin-specific protease inhibitors | 瓦洛健康公司 | 2022-01-14 | — | — | CN | disclosed |
| EP-3414252-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139778-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2017-08-17 | — | — | WO | disclosed |