Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 15/20 | 0.57 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.44 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19212401 | 0.89 | P2RY12 (0.54) | P2RY12 | |
| SCHEMBL19210903 | 0.84 | GRM5 (0.50) | P2RY12MAPT | |
| SCHEMBL19210942 | 0.78 | SMN1; SMN2 (0.56) | MAPT | |
| SCHEMBL28680929 | 0.77 | P2RY12 (0.43) | P2RY12CXCR3MAPTUSP28USP25 | |
| SCHEMBL19212199 | 0.76 | SMN1; SMN2 (0.45) | P2RY12KDM4EMAPT | |
| SCHEMBL19212115 | 0.75 | GRM5 (0.51) | MAPTUSP28USP25 | |
| SCHEMBL19212112 | 0.75 | LMNA (0.44) | MAPTUSP28USP25 | |
| SCHEMBL27927939 | 0.74 | KMT2A (0.47) | P2RY12KDM4EMAPT | |
| SCHEMBL21457818 | 0.74 | BACE1 (0.48) | MAPT | |
| SCHEMBL3924709 | 0.73 | P2RY12 (1.00) | P2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414252-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | Forma Therapeutics, Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017139778-A1 | THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2017-08-17 | — | — | WO | disclosed |