Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SLC13A5 | Q86YT5 | 6/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.35 |
| ▸ | HMGCR | P04035 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | SLC13A2 | Q13183 | 1/20 | 0.33 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL28625108 | 0.94 | ALOX15 (0.59) | ALOX15ALDH1A1SLC13A5HIF1AEPAS1 | |
| Linalool SCHEMBL28058703 | 0.85 | ALOX15 (0.85) | ALOX15HIF1AEPAS1TSHRKDM4E | |
| Linalool SCHEMBL28503155 | 0.85 | ALOX15 (0.85) | ALOX15HIF1AEPAS1TSHRKDM4E | |
| Linalool SCHEMBL1471881 | 0.85 | ALOX15 (0.85) | ALOX15HIF1AEPAS1TSHRKDM4E | |
| Linalool SCHEMBL29016516 | 0.84 | ALOX15 (0.76) | ALOX15HIF1AEPAS1TSHRKDM4E | |
| Linalool SCHEMBL28058609 | 0.84 | ALOX15 (0.81) | ALOX15HIF1AEPAS1TSHRKDM4E | |
| Linalool SCHEMBL30598848 | 0.84 | ALOX15 (0.65) | ALOX15HIF1AEPAS1HMGCRCHRM1 | |
| Linalool SCHEMBL14721882 | 0.83 | ALOX15 (0.96) | ALOX15ALDH1A1HIF1AEPAS1TSHR | |
| SCHEMBL5554363 | 0.82 | ALDH1A1 (0.52) | ALOX15ALDH1A1SLC13A5HIF1AHMGCR | |
| SCHEMBL1733822 | 0.82 | ALDH1A1 (0.52) | ALOX15ALDH1A1SLC13A5HIF1AHMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120040563-A | Arabinose response transcription factor assembly and application thereof | 中国科学院深圳先进技术研究院 | 2025-05-27 | — | — | CN | disclosed |
| WO-2017138003-A1 | ANTIMICROBIAL PRESERVATIVE COMPOSITIONS | SHARON LABORATORIES LTD. (IL) | 2017-08-17 | — | — | WO | disclosed |