Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11779617 | 0.84 | SMN1; SMN2 (0.69) | MAPTALDH1A1L3MBTL1KDM4ENPC1 | |
| SCHEMBL11779616 | 0.84 | SMN1; SMN2 (0.69) | MAPTALDH1A1L3MBTL1KDM4ENPC1 | |
| SCHEMBL19215161 | 0.84 | PRMT5 (0.56) | MAPTALDH1A1L3MBTL1KDM4ENPC1 | |
| SCHEMBL2318474 | 0.77 | KDM4E (0.67) | MAPTALDH1A1L3MBTL1KDM4ENPC1 | |
| SCHEMBL4343079 | 0.75 | NQO2 (0.53) | MAPTALDH1A1L3MBTL1KDM4ENPC1 | |
| SCHEMBL4329656 | 0.74 | MAPT (1.00) | MAPTALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL4329650 | 0.74 | MAPT (1.00) | MAPTALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL29219636 | 0.73 | POLB (0.57) | MAPTALDH1A1L3MBTL1KDM4ENPC1 | |
| SCHEMBL29219632 | 0.73 | POLB (0.57) | MAPTALDH1A1L3MBTL1KDM4ENPC1 | |
| SCHEMBL14541695 | 0.73 | NQO2 (0.52) | MAPTALDH1A1L3MBTL1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725429-B2 | Furanyl-imine and thiofuranyl-imine compounds for stabilizing ryanodine receptors from aberrant levels of calcium release | ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE (US) | 2017-08-08 | — | — | US | disclosed |