Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.71 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.71 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | TYMS | P04818 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | P4HB | P07237 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17723998 | 0.83 | CYP11B1 (1.00) | CYP11B1CYP11B2MRGPRX4PLAUUSP30 | |
| SCHEMBL19212927 | 0.82 | CYP11B1 (0.68) | CYP11B1CYP11B2MRGPRX4PLAUTP53 | |
| SCHEMBL29228749 | 0.74 | CYP11B1 (0.54) | CYP11B1CYP11B2MRGPRX4PLAUUSP30 | |
| SCHEMBL19213005 | 0.74 | CYP11B1 (0.67) | CYP11B1CYP11B2MRGPRX4USP30AR | |
| SCHEMBL30444713 | 0.73 | MRGPRX4 (0.56) | CYP11B1CYP11B2MRGPRX4PLAUTP53 | |
| SCHEMBL60040 | 0.73 | MRGPRX4 (0.56) | CYP11B1CYP11B2MRGPRX4PLAUTP53 | |
| SCHEMBL26814282 | 0.72 | CYP11B1 (0.80) | CYP11B1CYP11B2MRGPRX4MEN1LMNA | |
| SCHEMBL6578619 | 0.71 | CYP11B1 (0.55) | CYP11B1CYP11B2MRGPRX4PLAUTP53 | |
| SCHEMBL6831985 | 0.71 | CYP11B1 (0.52) | CYP11B1CYP11B2MRGPRX4PLAU | |
| SCHEMBL17714132 | 0.71 | CYP11B1 (0.52) | CYP11B1CYP11B2MRGPRX4PLAUAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790217-B2 | Pyridinyloxy- and phenyloxy-pyrazolyl compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-10-17 | — | — | US | disclosed |
| US-20170226097-A1 | PYRIDINYLOXY- AND PHENYLOXY-PYRAZOLYL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2017-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170226097-A1 | PYRIDINYLOXY- AND PHENYLOXY-PYRAZOLYL COMPOUNDS | PDXK, PNPO, PAH | CYP11B1 84/4885CYP11B2 32/4885MRGPRX4 274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.