⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL87648 | 0.80 | — | — | |
| SCHEMBL27738429 | 0.80 | — | — | |
| SCHEMBL27717369 | 0.80 | — | — | |
| SCHEMBL995740 | 0.79 | — | — | |
| SCHEMBL18987284 | 0.78 | LMNA (0.48) | — | |
| SCHEMBL6543496 | 0.78 | LMNA (0.48) | — | |
| SCHEMBL28765755 | 0.78 | LMNA (0.48) | — | |
| SCHEMBL9451858 | 0.76 | MEN1 (0.34) | — | |
| SCHEMBL417149 | 0.76 | CYP19A1 (0.33) | — | |
| SCHEMBL29728566 | 0.75 | TSHR (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260035360-A1 | INHIBITORS OF MYC AND USES THEREOF | UNIV NORTHWESTERN (US) | 2026-02-05 | — | — | US | disclosed |
| CN-113272309-B | Tricyclic inhibitors of hepatitis b virus | 圣拉斐尔医院有限公司 | 2024-02-23 | — | — | CN | disclosed |
| EP-2988597-B1 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | HARVARD COLLEGE (US) | 2022-06-08 | — | — | EP | disclosed |
| CN-110475777-B | Novel pyrido [2,3-b ] indole compounds for the treatment and prevention of bacterial infections | 豪夫迈·罗氏有限公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-114173824-A | Antibody drug conjugates | 武田药品工业株式会社 | 2022-03-11 | — | — | CN | disclosed |
| US-10913764-B2 | Macrolides and methods of their preparation and use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-02-09 | — | — | US | disclosed |
| US-20180298048-A1 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-10-18 | — | — | US | disclosed |
| US-9982005-B2 | Macrolides and methods of their preparation and use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-05-29 | — | — | US | disclosed |
| EP-2988597-A2 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | President and Fellows of Harvard College (US) | 2016-03-02 | — | — | EP | disclosed |
| US-20160052951-A1 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-02-25 | — | — | US | disclosed |
| EP-2327705-B1 | Podophyllotoxins as antiproliferative agents | UNIVERSITÄTSKLINIKUM CHARITÉ DER HUMBOLDT UNIVERSITÄT ZU BERLIN (DE) | 2015-05-27 | — | — | EP | disclosed |
| WO-2014165792-A2 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-10-09 | — | — | WO | disclosed |
| EP-2327705-A1 | Podophyllotoxins as antiproliferative agents | Universitätsklinikum Charité der Humboldt- Universität zu Berlin (DE) | 2011-06-01 | — | — | EP | disclosed |
| EP-1451193-B1 | PODOPHYLLOTOXINS AS ANTIPROLIFERATIVE AGENTS | UNIVERSITAETSKLINIKUM CHARITE (DE) | 2010-10-06 | — | — | EP | disclosed |
| US-7582778-B2 | Podophyllotoxin | UNIVERSITATSKLINIKUM CHARITE DER HUMBOLDT-UNIVERSITAT ZU (DE) | 2009-09-01 | — | — | US | disclosed |
| US-20060293254-A1 | enzyme inhibitors of topoisomerase as anticancer, antitumor, antifungal and/or microbiocides; ; etoposide and teniposide; prodrugs; water solubility, stability | UNIVERSITATSKLINIKUM CHARITE DER HUMBOLDT-UNIVERSITAT ZU (DE) | 2006-12-28 | — | — | US | disclosed |
| EP-1451193-A1 | PODOPHYLLOTOXINS AS ANTIPROLIFERATIVE AGENTS | Universitätsklinikum Charité der Humboldt- Universität zu Berlin (DE) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003048166-A1 | PODOPHYLLOTOXINS AS ANTIPROLIFERATIVE AGENTS | UNIVERSITÄTSKLINIKUM CHARITE DER HUMBOLDT-UNIVERSITÄT ZU BERLIN TECHNOLOGIE TRANSFERSTELLE (DE) | 2003-06-12 | — | — | WO | disclosed |