Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | CASP1 | P29466 | 1/20 | 0.62 |
| ▸ | CASP7 | P55210 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | CA12 | O43570 | 2/20 | 0.59 |
| ▸ | CA1 | P00915 | 2/20 | 0.59 |
| ▸ | CA2 | P00918 | 2/20 | 0.59 |
| ▸ | CA9 | Q16790 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27363823 | 0.87 | TDP1 (0.61) | SMN1; SMN2MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL26706252 | 0.87 | MAPT (0.69) | SMN1; SMN2MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL27364761 | 0.86 | TDP1 (0.60) | SMN1; SMN2MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL18500553 | 0.83 | MAPT (0.62) | SMN1; SMN2MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL11892961 | 0.82 | SMN1; SMN2 (0.68) | SMN1; SMN2MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL520513 | 0.80 | KMT2A (0.58) | SMN1; SMN2MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL19187554 | 0.77 | TDP1 (0.73) | SMN1; SMN2MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL314647 | 0.77 | CHRM4 (0.55) | SMN1; SMN2MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL24324251 | 0.76 | MAPT (0.55) | SMN1; SMN2MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL521306 | 0.76 | SIRT6 (0.65) | SMN1; SMN2MAPTKMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180185363-A1 | PHTHALAZINONE DERIVATIVES | KUDOS PHARMACEUTICALS LIMITED (GB) | 2018-07-05 | — | — | US | disclosed |
| US-20170226124-A1 | PHTHALAZINONE DERIVATIVES | KUDOS PHARMACEUTICALS LIMITED (GB) | 2017-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170226124-A1 | PHTHALAZINONE DERIVATIVES | NR0B1, NR0B2, NR2E1 | SMN1; SMN2 3650/4885MAPT 4216/4885KMT2A 2142/4885 |
| US-20180185363-A1 | PHTHALAZINONE DERIVATIVES | NR0B1, NR0B2, NR2E1 | SMN1; SMN2 3730/4885MAPT 4208/4885KMT2A 2203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.