Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | BPTF | Q12830 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 8/20 | 0.36 |
| ▸ | HTR2A | P28223 | 7/20 | 0.36 |
| ▸ | HTR2B | P41595 | 7/20 | 0.36 |
| ▸ | OGA | O60502 | 1/20 | 0.34 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17519369 | 0.82 | NR1H2 (0.49) | HRH3HTR2CHTR2AHTR2BOGA | |
| Hydrochloric Acid SCHEMBL27839061 | 0.79 | BPTF (0.41) | BPTFHRH3GRIN2DGRIN3BGRIN1 | |
| SCHEMBL15542777 | 0.75 | HTR3A (0.45) | TLR9TLR8TLR7 | |
| SCHEMBL6798958 | 0.75 | PANK3 (0.36) | TLR9TLR8TLR7GRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL4003712 | 0.75 | IKBKB (0.38) | — | |
| SCHEMBL19214346 | 0.71 | NR1H2 (0.37) | TLR9TLR8TLR7HTR2CHTR2A | |
| SCHEMBL38664196 | 0.71 | ADRB2 (0.46) | TLR9TLR8TLR7HTR2CHTR2A | |
| SCHEMBL27619754 | 0.71 | TLR9 (0.37) | TLR9TLR8TLR7HTR2CHTR2A | |
| SCHEMBL82373 | 0.71 | BPTF (0.64) | BPTFHRH3GRIN2DGRIN3BGRIN1 | |
| SCHEMBL29902963 | 0.71 | BPTF (0.64) | BPTFHRH3GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170226067-A1 | PIPERAZINE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | VITAE PHARMACEUTICALS, INC. (US) | 2017-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170226067-A1 | PIPERAZINE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | NR1H2, NR1H3, NR1I2 | TLR9 1455/4885TLR8 1336/4885TLR7 641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.