Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.68 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | PKM | P14618 | 3/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.54 |
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
| ▸ | MMP13 | P45452 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | YAP1 | P46937 | 1/20 | 0.53 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.53 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8334686 | 0.86 | ADAM17 (0.71) | KMT2AMEN1PKMGAANPSR1 | |
| SCHEMBL12730569 | 0.86 | ADAM17 (0.71) | KMT2AMEN1PKMGAANPSR1 | |
| SCHEMBL12730849 | 0.86 | ADAM17 (0.71) | KMT2AMEN1PKMGAANPSR1 | |
| SCHEMBL12730547 | 0.85 | KMT2A (0.64) | KMT2AMEN1PKMGAANPSR1 | |
| SCHEMBL19215172 | 0.82 | KDM4E (0.48) | KMT2AMEN1PKMGAAALDH1A1 | |
| SCHEMBL8324207 | 0.81 | GAA (0.68) | KMT2AMEN1PKMGAANPSR1 | |
| SCHEMBL16080246 | 0.81 | DHCR7 (0.73) | KMT2AMEN1SMN1; SMN2TDP1 | |
| SCHEMBL10175759 | 0.81 | DHCR7 (0.73) | KMT2AMEN1SMN1; SMN2TDP1 | |
| SCHEMBL10050562 | 0.80 | KDM4E (0.73) | KMT2AMEN1PKMGAANPSR1 | |
| SCHEMBL15866264 | 0.80 | ALDH1A1 (0.62) | KMT2AMEN1PKMALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725442-B2 | Heterocyclic derivative having PGD2 receptor antagonist activity | SHIONOGI & CO., LTD. (JP) | 2017-08-08 | — | — | US | disclosed |