Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11527220 | 0.89 | THRB (0.39) | TLR4ALDH1A1PTPN1MAPTNPC1 | |
| SCHEMBL27441555 | 0.84 | THRB (0.31) | TLR4THRB | |
| SCHEMBL10248877 | 0.84 | ALDH1A1 (0.39) | TLR4ALDH1A1PTPN1MAPTNPC1 | |
| SCHEMBL27676219 | 0.82 | FOLH1 (0.40) | ALDH1A1MAPTPOLBTDP1 | |
| SCHEMBL5274773 | 0.81 | CYP1A2 (0.45) | TLR4ALDH1A1 | |
| SCHEMBL19213538 | 0.80 | MAPT (0.33) | MAPTTHRB | |
| SCHEMBL6520162 | 0.80 | TSHR (0.40) | ALDH1A1MAPTTHRBTDP1 | |
| SCHEMBL26828383 | 0.78 | ALDH1A1 (0.41) | ALDH1A1MAPTTDP1 | |
| SCHEMBL26205593 | 0.77 | TLR4 (0.42) | TLR4ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL23352594 | 0.76 | MAPT (0.41) | TLR4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725402-B2 | Nitroso compounds as nitroxyl donors and methods of use thereof | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2017-08-08 | — | — | US | disclosed |