Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 5/20 | 0.56 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | TYR | P14679 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18098004 | 0.89 | P4HB (0.68) | P4HBTTRAPPPTPN1EPHX2 | |
| SCHEMBL1410893 | 0.83 | P4HB (0.57) | P4HBTTRAPPPTPN1EPHX2 | |
| SCHEMBL1410896 | 0.83 | P4HB (0.57) | P4HBTTRAPPPTPN1EPHX2 | |
| SCHEMBL31021318 | 0.83 | P4HB (0.57) | P4HBTTRAPPPTPN1EPHX2 | |
| SCHEMBL4423599 | 0.83 | P4HB (0.53) | P4HBTTRAPPPTPN1EPHX2 | |
| SCHEMBL69618 | 0.82 | TTR (0.66) | P4HBTTRAPPPTPN1EPHX2 | |
| SCHEMBL6171568 | 0.82 | PARP1 (0.59) | P4HBTTRAPPPTPN1EPHX2 | |
| SCHEMBL4827946 | 0.82 | TTR (0.54) | P4HBTTRAPPPTPN1EPHX2 | |
| SCHEMBL6171570 | 0.82 | PARP1 (0.59) | P4HBTTRAPPPTPN1EPHX2 | |
| SCHEMBL4827950 | 0.82 | TTR (0.54) | P4HBTTRAPPPTPN1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725407-B2 | HDAC inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-08-08 | — | — | US | disclosed |