Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL304973 | 0.84 | JAK3 (0.36) | METAP2METAP1BRD4BRD9 | |
| SCHEMBL1922562 | 0.79 | NPY5R (0.38) | NPY5R | |
| SCHEMBL304148 | 0.77 | JAK2 (0.33) | — | |
| SCHEMBL302220 | 0.76 | NPY5R (0.35) | NPY5R | |
| SCHEMBL305389 | 0.76 | CARM1 (0.37) | BRD4BRD9 | |
| SCHEMBL302466 | 0.76 | AR (0.34) | BRD4BRD9 | |
| SCHEMBL305500 | 0.75 | TNIK (0.34) | BRD4 | |
| SCHEMBL305998 | 0.74 | ACP1 (0.35) | — | |
| SCHEMBL2027187 | 0.71 | JAK2 (0.35) | — | |
| SCHEMBL304002 | 0.70 | CARM1 (0.37) | BRD4BRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328871-A2 | HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010027746-A2 | HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2010-03-11 | — | — | WO | disclosed |