Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL305500 | 0.88 | TNIK (0.34) | — | |
| SCHEMBL304149 | 0.85 | JAK2 (0.34) | JAK2 | |
| SCHEMBL1922562 | 0.82 | NPY5R (0.38) | — | |
| SCHEMBL302220 | 0.81 | NPY5R (0.35) | — | |
| SCHEMBL1922064 | 0.77 | METAP2 (0.32) | — | |
| SCHEMBL305998 | 0.77 | ACP1 (0.35) | — | |
| SCHEMBL27935539 | 0.76 | PIK3CA (0.35) | JAK2 | |
| SCHEMBL302466 | 0.75 | AR (0.34) | — | |
| SCHEMBL305389 | 0.74 | CARM1 (0.37) | — | |
| SCHEMBL305501 | 0.73 | TNIK (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500853-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2328871-A2 | HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2011-06-08 | — | — | EP | claimed |
| WO-2010027746-A2 | HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2010-03-11 | — | — | WO | claimed |