Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17512979 | 0.88 | CYP3A4 (0.74) | CYP3A4CYP1A2CYP2D6CYP2C9NFKB1 | |
| SCHEMBL14355533 | 0.85 | CYP3A4 (0.57) | CYP3A4CYP1A2CYP2D6CYP2C9NFKB1 | |
| SCHEMBL9669395 | 0.85 | CYP3A4 (0.58) | CYP3A4CYP1A2CYP2D6CYP2C9NFKB1 | |
| SCHEMBL19220803 | 0.84 | CYP3A4 (0.56) | CYP3A4CYP1A2CYP2D6CYP2C9NFKB1 | |
| SCHEMBL873285 | 0.83 | CYP3A4 (0.55) | CYP3A4CYP1A2CYP2D6CYP2C9NFKB1 | |
| SCHEMBL9669441 | 0.83 | CYP3A4 (0.49) | CYP3A4CYP1A2CYP2D6CYP2C9NFKB1 | |
| SCHEMBL9669467 | 0.83 | CYP3A4 (0.56) | CYP3A4CYP1A2CYP2D6CYP2C9NFKB1 | |
| SCHEMBL9669136 | 0.82 | CYP3A4 (0.55) | CYP3A4CYP1A2CYP2D6CYP2C9NFKB1 | |
| SCHEMBL25340610 | 0.81 | CTSK (0.49) | CYP3A4CYP1A2CYP2D6CYP2C9NFKB1 | |
| SCHEMBL27926127 | 0.80 | CYP3A4 (0.48) | CYP3A4CYP1A2CYP2D6CYP2C9NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170226059-A1 | APOE4-TARGETED THERAPUTICS THAT INCREASE SIRT1 | BUCK INSTITUTE FOR RESEARCH ON AGING | 2017-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170226059-A1 | APOE4-TARGETED THERAPUTICS THAT INCREASE SIRT1 | SIRT1, PSEN2, PSEN1 | CYP3A4 4596/4885CYP1A2 4125/4885CYP2D6 4660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.