Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.42 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15281988 | 1.00 | NPSR1 (0.42) | NPSR1GLO1ALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL19223 | 1.00 | NPSR1 (0.42) | NPSR1GLO1ALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL251634 | 0.86 | NPSR1 (0.44) | NPSR1GLO1ALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL215091 | 0.86 | NPSR1 (0.44) | NPSR1GLO1ALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL5188862 | 0.86 | NPSR1 (0.44) | NPSR1GLO1ALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL5074733 | 0.85 | NPSR1 (0.43) | NPSR1GLO1ALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL1828800 | 0.83 | NPSR1 (0.42) | NPSR1GLO1ALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL1828802 | 0.83 | NPSR1 (0.42) | NPSR1GLO1ALDH1A1CYP2D6SMN1; SMN2 | |
| SCHEMBL433731 | 0.83 | — | — | |
| SCHEMBL20679053 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-10120658-A | — | — | None | — | — | JP | disclosed |
| US-11299463-B2 | Process for the manufacture of pyrazoles or pyrimidones | FUJIAN YONGJING TECHNOLOGY CO., LTD. (CN) | 2022-04-12 | — | — | US | disclosed |
| EP-3650443-A1 | CONTINUOUS FLOW SYNTHESIS OF FLUORINATED OR NON-FLUORINATED PYRAZOLES | Fujian Yongjing Technology Co., Ltd. (CN) | 2020-05-13 | — | — | EP | disclosed |
| US-20200140390-A1 | Process for the Manufacture of Pyrazoles or Pyrimidones | FUJIAN YONGJING TECHNOLOGY CO., LTD. (CN) | 2020-05-07 | — | — | US | disclosed |
| EP-2595962-B1 | PROCESS FOR THE PREPARATION OF ESTERS OF 1-SUBSTITUTED-3-FLUOROALKYL-PYRAZOLE-4-CARBOXYLIC ACIDS | SOLVAY (BE) | 2018-07-11 | — | — | EP | disclosed |
| EP-3178813-A1 | METHOD FOR PREPARING HALOGENATED 3-OXOCARBOXYLATES CARRYING A 2-ALKOXYMETHYLIDENE OR A 2-DIALKYLAMINOMETHYLIDENE GROUP | BASF SE (DE) | 2017-06-14 | — | — | EP | disclosed |
| EP-2671874-B1 | Preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids | SOLVAY (BE) | 2016-01-13 | — | — | EP | disclosed |
| US-8981116-B2 | Process for the preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids | SOLVAY SA (BE) | 2015-03-17 | — | — | US | disclosed |
| EP-2671874-A1 | Preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids | SOLVAY SA (BE) | 2013-12-11 | — | — | EP | disclosed |
| EP-2595962-A1 | PROCESS FOR THE PREPARATION OF ESTERS OF 1-SUBSTITUTED-3-FLUOROALKYL-PYRAZOLE-4-CARBOXYLIC ACIDS | SOLVAY SA (BE) | 2013-05-29 | — | — | EP | disclosed |
| US-20130123510-A1 | Process for the preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids | SOLVAY SA (BE) | 2013-05-16 | — | — | US | disclosed |
| WO-2012025469-A1 | IMPROVED PROCESS FOR THE PREPARATION OF ESTERS OF 1-H-PYRAZOLE-4-CARBOXYLIC ACIDS | SOLVAY SA (BE) | 2012-03-01 | — | — | WO | disclosed |
| WO-2012010692-A1 | PROCESS FOR THE PREPARATION OF ESTERS OF 1-SUBSTITUTED-3-FLUOROALKYL-PYRAZOLE-4-CARBOXYLIC ACIDS | SOLVAY SA (BE) | 2012-01-26 | — | — | WO | disclosed |
| JP-H10120658-A | 4-DIFLUOROHALOGENOMETHYL-5-IMINOMETHYLPYRIMIDINE DERIVATIVE | NISSAN CHEM IND LTD | 1998-05-12 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200140390-A1 | Process for the Manufacture of Pyrazoles or Pyrimidones | DHFR, CYP4X1, CYP2F1 | NPSR1 447/4885GLO1 1720/4885ALDH1A1 613/4885 |
| US-20130123510-A1 | Process for the preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids | CYP2F1, KHK, CYP4F3 | NPSR1 3301/4885GLO1 1084/4885ALDH1A1 367/4885 |
| US-11299463-B2 | Process for the manufacture of pyrazoles or pyrimidones | DHFR, CYP4X1, CYP2F1 | NPSR1 433/4885GLO1 1704/4885ALDH1A1 636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.