SCHEMBL433731

SCHEMBL433731

CCO/C=C(/C(=O)O)C(=O)C(F)(F)Cl

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL433732 1.00
SCHEMBL8561713 0.86 GLO1 (0.36)
SCHEMBL8563856 0.86 GLO1 (0.36)
SCHEMBL20679053 0.86
SCHEMBL20679054 0.86
SCHEMBL20693314 0.86
SCHEMBL1336752 0.85
SCHEMBL1336751 0.85
SCHEMBL3997999 0.85
SCHEMBL8564942 0.84

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2595962-B1 PROCESS FOR THE PREPARATION OF ESTERS OF 1-SUBSTITUTED-3-FLUOROALKYL-PYRAZOLE-4-CARBOXYLIC ACIDS SOLVAY (BE) 2018-07-11 EP disclosed
EP-2671874-B1 Preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids SOLVAY (BE) 2016-01-13 EP disclosed
US-8981116-B2 Process for the preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids SOLVAY SA (BE) 2015-03-17 US disclosed
EP-2671874-A1 Preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids SOLVAY SA (BE) 2013-12-11 EP disclosed
EP-2595962-A1 PROCESS FOR THE PREPARATION OF ESTERS OF 1-SUBSTITUTED-3-FLUOROALKYL-PYRAZOLE-4-CARBOXYLIC ACIDS SOLVAY SA (BE) 2013-05-29 EP disclosed
EP-2257532-B1 METHOD FOR REGIOSELECTIVE SYNTHESIS OF 1-ALKYL-3-HALOALKYL-1-PYRAZOL-4-CARBONIC ACID DERIVATIVES BAYER CROPSCIENCE AG (DE) 2013-05-29 EP disclosed
US-20130123510-A1 Process for the preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids SOLVAY SA (BE) 2013-05-16 US disclosed
WO-2012010692-A1 PROCESS FOR THE PREPARATION OF ESTERS OF 1-SUBSTITUTED-3-FLUOROALKYL-PYRAZOLE-4-CARBOXYLIC ACIDS SOLVAY SA (BE) 2012-01-26 WO disclosed
EP-2257532-A1 PROCESS FOR THE REGIOSELECTIVE SYNTHESIS OF L-ALKYL-3-HALOALKYLPYRAZOLE-4-CARBOXYLIC ACID DERIVATIVES BAYER CROPSCIENCE AG (DE) 2010-12-08 EP disclosed
EP-2247577-A2 METHOD FOR THE REGIOSELECTIVE SYNTHESIS OF 1-ALKYL-3-HALOALKYL PYROAZOLE-4-CARBOXYLIC ACID DERIVATIVES BAYER CROPSCIENCE AG (DE) 2010-11-10 EP disclosed
WO-2009112157-A1 PROCESS FOR THE REGIOSELECTIVE SYNTHESIS OF L-ALKYL-3-HALOALKYLPYRAZOLE-4-CARBOXYLIC ACID DERIVATIVES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2009-09-17 WO disclosed
EP-2100883-A1 Method for regioselective synthesis of 1-alkyl-3-haloalkyl-1-pyrazol-4-carbonic acid derivatives Bayer CropScience AG (DE) 2009-09-16 EP disclosed
WO-2009106230-A2 METHOD FOR THE REGIOSELECTIVE SYNTHESIS OF 1-ALKYL-3-HALOALKYL–PYROAZOLE-4-CARBOXYLIC ACID DERIVATIVES BAYER CROPSCIENCE AKTENGESELLSCHAFT (DE) 2009-09-03 WO disclosed