⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL872465 | 0.81 | GAA (0.32) | — | |
| SCHEMBL872466 | 0.79 | — | — | |
| SCHEMBL3290255 | 0.79 | — | — | |
| SCHEMBL12285214 | 0.79 | — | — | |
| SCHEMBL8813250 | 0.79 | — | — | |
| SCHEMBL8811134 | 0.77 | — | — | |
| SCHEMBL8811138 | 0.77 | — | — | |
| SCHEMBL1921788 | 0.77 | — | — | |
| SCHEMBL15700687 | 0.77 | EPHX1 (0.31) | — | |
| SCHEMBL18657151 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-11269138-A | — | — | None | — | — | JP | disclosed |
| US-12365927-B2 | Engineered ketoreductase polypeptides | CODEXIS, INC. (US) | 2025-07-22 | — | — | US | disclosed |
| US-20230104779-A1 | ENGINEERED KETOREDUCTASE POLYPEPTIDES | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2023-04-06 | — | — | US | disclosed |
| US-11512332-B2 | Engineered ketoreductase polypeptides | CODEXIS, INC. (US) | 2022-11-29 | — | — | US | disclosed |
| US-20200340025-A1 | ENGINEERED KETOREDUCTASE POLYPEPTIDES | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2020-10-29 | — | — | US | disclosed |
| US-10752926-B2 | Engineered ketoreductase polypeptides | CODEXIS, INC. (US) | 2020-08-25 | — | — | US | disclosed |
| US-10731004-B2 | Polyimide precursor composition and use thereof | ETERNAL MATERIALS CO., LTD. (TW) | 2020-08-04 | — | — | US | disclosed |
| US-10626220-B2 | Precursor for polyimide and use thereof | ETERNAL MATERIALS CO., LTD. (TW) | 2020-04-21 | — | — | US | disclosed |
| US-10626220-B2 | Precursor for polyimide and use thereof | ETERNAL MATERIALS CO., LTD. (TW) | 2020-04-21 | — | — | US | disclosed |
| US-20180251802-A1 | ENGINEERED KETOREDUCTASE POLYPEPTIDES | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2018-09-06 | — | — | US | disclosed |
| US-20100173369-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE | CODEXIS, INC. (US) | 2010-07-08 | — | — | US | disclosed |
| US-20100151534-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF A 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE | CODEXIS, INC. (US) | 2010-06-17 | — | — | US | disclosed |
| WO-2010025287-A2 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE | CODEXIS, INC. (US) | 2010-03-04 | — | — | WO | disclosed |
| WO-2010025238-A2 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF A 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE | CODEXIS, INC. (US) | 2010-03-04 | — | — | WO | disclosed |
| US-20060167278-A1 | Propanolamine derivatives, process for preparation of 3-n-methylamino-1-(2-thienyl)-1-propanols and process for preparation of propanolamine derivatives | MITSUBISHI RAYON CO. LTD. (JP) | 2006-07-27 | — | — | US | disclosed |
| CN-1649870-A | 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases | ACTELION PHARMACEUTICALS LTD (CH) | 2005-08-03 | — | — | CN | disclosed |
| EP-1506965-A1 | PROPANOLAMINE DERIVATIVES, PROCESS FOR PREPARATION OF 3-N-METHYLAMINO-1-(2-THIENYL)-1-PROPANOLS AND PROCESS FOR PREPARATION OF PROPANOLAMINE DERIVATIVES | Mitsubishi Rayon Co., Ltd. (JP) | 2005-02-16 | — | — | EP | disclosed |
| JP-H11269138-A | ORGANIC BASE PRODUCING AGENT | MITSUBISHI PAPER MILLS LTD | 1999-10-05 | — | — | JP | disclosed |
| EP-0508261-A2 | Process for preparing beta-halogen tert.alkyl carboxylic acid chlorides | BAYER AG (DE) | 1992-10-14 | — | — | EP | disclosed |
| US-3998816-A | 7-[5-N-(n-Butoxyethoxy carbonyl and 2-chloroethoxy carbonyl)-amino] cephalosporins C | MEIJI SEIKA KAISHA, LTD. (JA) | 1976-12-21 | — | — | US | disclosed |