Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.52 |
| ▸ | SNCA | P37840 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | PNMT | P11086 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | TDP2 | O95551 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29485953 | 1.00 | MEN1 (0.54) | MEN1KMT2AMAPTKDM4EGAA | |
| SCHEMBL30270534 | 0.82 | CA9 (0.56) | KMT2AMAPTKDM4ESIRT2NPC1 | |
| SCHEMBL495833 | 0.82 | CA9 (0.56) | KMT2AMAPTKDM4ESIRT2NPC1 | |
| SCHEMBL27481409 | 0.78 | PNMT (0.44) | MEN1KMT2AMAPTSIRT2NPC1 | |
| SCHEMBL10061497 | 0.78 | KMT2A (0.50) | MEN1KMT2AMAPTSIRT2SNCA | |
| SCHEMBL2061055 | 0.76 | MAPT (0.51) | MAPTSIRT2NPC1ADRA2APNMT | |
| SCHEMBL31378863 | 0.75 | PNMT (0.58) | MEN1KMT2AMAPTSIRT2NPC1 | |
| SCHEMBL27931452 | 0.75 | PTPRC (0.54) | MEN1KMT2AMAPTGAANPC1 | |
| SCHEMBL427407 | 0.75 | PNMT (0.58) | MEN1KMT2AMAPTSIRT2NPC1 | |
| SCHEMBL7154079 | 0.74 | MAPT (0.49) | MEN1KMT2AMAPTSIRT2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12403144-B2 | HECT E3 ligase inhibitors and uses thereof | IFOM —FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE (IT) | 2025-09-02 | — | — | US | disclosed |
| EP-3976185-B1 | HECT E3 LIGASE INHIBITORS AND USES THEREOF | IFOM ST FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS (IT) | 2024-02-14 | — | — | EP | disclosed |
| US-20220339163-A1 | HECT E3 LIGASE INHIBITORS AND USES THEREOF | IFOM - FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE (IT) | 2022-10-27 | — | — | US | disclosed |
| WO-2020245213-A1 | HECT E3 LIGASE INHIBITORS AND USES THEREOF | IFOM - FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE (IT) | 2020-12-10 | — | — | WO | disclosed |
| US-9908890-B2 | Selective inhibitors of constitutive androstane receptor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2018-03-06 | — | — | US | disclosed |
| US-20170226115-A1 | SELECTIVE INHIBITORS OF CONSTITUTIVE ANDROSTANE RECEPTOR | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-08-10 | — | — | US | disclosed |
| US-20170226115-A1 | SELECTIVE INHIBITORS OF CONSTITUTIVE ANDROSTANE RECEPTOR | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220339163-A1 | HECT E3 LIGASE INHIBITORS AND USES THEREOF | NEDD4, ITCH, UBE3A | MEN1 3981/4885KMT2A 735/4885MAPT 365/4885 |
| US-12403144-B2 | HECT E3 ligase inhibitors and uses thereof | NEDD4, ITCH, UBE3A | MEN1 3981/4885KMT2A 735/4885MAPT 365/4885 |
| US-20170226115-A1 | SELECTIVE INHIBITORS OF CONSTITUTIVE ANDROSTANE RECEPTOR | NR1I2, NR1I3, AR | MEN1 4383/4885KMT2A 3595/4885MAPT 2875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.