SCHEMBL19225136

SCHEMBL19225136

CC(Cl)c1cccc(C(=O)Cl)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
PTGS1 P23219 3/20 0.46
PTGS2 P35354 3/20 0.46
MAPT P10636 3/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
CXCR1 P25024 2/20 0.46
CXCR2 P25025 2/20 0.46
KDM4E B2RXH2 2/20 0.46
CYP3A4 P08684 2/20 0.46
HPGD P15428 2/20 0.46
HSD17B10 Q99714 2/20 0.46
RECQL P46063 1/20 0.46
LMNA P02545 1/20 0.46
MAPK1 P28482 1/20 0.46
PMP22 Q01453 1/20 0.46
SLC22A6 Q4U2R8 1/20 0.46
CXCL8 P10145 1/20 0.46
THPO P40225 1/20 0.46
HIF1A Q16665 1/20 0.46
TSHR P16473 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3887369 0.88 RXRA (0.51) ALDH1A1PTGS1PTGS2MAPTSMN1; SMN2
SCHEMBL73694 0.84 ALDH1A1 (0.47) ALDH1A1PTGS1PTGS2MAPTSMN1; SMN2
SCHEMBL215100 0.83 PARP1 (0.53) ALDH1A1PTGS1PTGS2MAPTSMN1; SMN2
SCHEMBL27646820 0.83 SMN1; SMN2 (0.45) ALDH1A1PTGS1PTGS2MAPTSMN1; SMN2
SCHEMBL465903 0.82 ALDH1A1 (0.46) ALDH1A1PTGS1PTGS2MAPTSMN1; SMN2
SCHEMBL13143831 0.82 ALDH1A1 (0.46) ALDH1A1PTGS1PTGS2MAPTSMN1; SMN2
SCHEMBL7161448 0.81 PTGS1 (0.70) ALDH1A1PTGS1PTGS2MAPTSMN1; SMN2
SCHEMBL25178901 0.79 ALDH1A1 (0.40) ALDH1A1PTGS1PTGS2MAPTSMN1; SMN2
SCHEMBL1891064 0.79 ALDH1A1 (0.41) ALDH1A1PTGS1PTGS2MAPTSMN1; SMN2
SCHEMBL27361509 0.79 MAPT (0.41) ALDH1A1PTGS1PTGS2MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2688942-B1 AROMATIC POLYAMIDE FILMS FOR TRANSPARENT FLEXIBLE SUBSTRATES AKRON POLYMER SYSTEMS INC (US) 2017-08-09 EP disclosed